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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Syndecan-3
Summary
- UniProt ID
- O75056
- Gene Symbol
-
- SDC3
- KIAA0468
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Cell membrane
- Heparan sulfate
- Phosphoprotein
- Reference proteome
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| cell migration |
| GO Term |
|---|
| plasma membrane |
| membrane |
| collagen-containing extracellular matrix |
| microspike |
| Golgi lumen |
| cell surface |
| lysosomal lumen |
| GO Term |
|---|
| identical protein binding |
Sequence
MKPGPPHRAGAAHGAGAGAGAAAGPGARGLLLPPLLLLLLAGRAAGAQRWRSENFERPVDLEGSGDDDSFPDDELDDLYSGSGSGYFEQESGIETAMRFSPDVALAVSTTPAVLPTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIRTTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTPETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKEVLVAVIVGGVVGALFAAFLVTLLIYRMKKKDEGSYTLEEPKQASVTYQKPDKQEEFYA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 80 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 82 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 84 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 91 | O-linked (Xyl...) (glycosaminoglycan) serine |
|
||
| 108 | O-linked (GalNAc) serine; by GALNT13 |
|
||
| 109 | O-linked (GalNAc) threonine; by GALNT13 |
|
||
| 110 | O-linked (GalNAc) threonine; by GALNT13 |
|
||
| 160 | O-linked (GalNAc) serine; by GALNT13 |
|
||
| 161 | O-linked (GalNAc) threonine; by GALNT13 |
|
||
| 162 | O-linked (GalNAc) threonine; by GALNT13 |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| Attachment and Entry | Homo sapiens |
| Cell surface interactions at the vascular wall | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | Homo sapiens |
| Defective EXT2 causes exostoses 2 | Homo sapiens |
| HS-GAG biosynthesis | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14525 | Reye syndrome | |
| DOID:162 | cancer | |
| DOID:1793 | pancreatic cancer | |
| DOID:1883 | hepatitis C | |
| DOID:3571 | liver cancer | |
| DOID:4450 | renal cell carcinoma | |
| DOID:4451 | renal carcinoma | |
| DOID:4464 | collecting duct carcinoma | |
| DOID:4465 | papillary renal cell carcinoma | |
| DOID:4467 | clear cell renal cell carcinoma |
