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MIRAGE
Inhibitor of nuclear factor kappa-B kinase subunit beta
Summary
- UniProt ID
- O88351
- Gene Symbol
-
- Ikbkb
- Ikkb
- Gene ID
- 16150
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- ATP-binding
- Cytoplasm
- Hydroxylation
- Isopeptide bond
- Membrane
- Nucleus
- Phosphoprotein
- Reference proteome
- S-nitrosylation
- Serine/threonine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| cytoplasmic side of plasma membrane |
| membrane raft |
| IkappaB kinase complex |
| CD40 receptor complex |
Sequence
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLESALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 600 |
|
|||
| 733 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of NF-kappaB in B cells | Mus musculus |
| CLEC7A (Dectin-1) signaling | Mus musculus |
| Downstream TCR signaling | Mus musculus |
| FCERI mediated NF-kB activation | Mus musculus |
| IKK complex recruitment mediated by RIP1 | Mus musculus |
| IRAK1 recruits IKK complex | Mus musculus |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | Mus musculus |
| Interleukin-1 signaling | Mus musculus |
| MAP3K8 (TPL2)-dependent MAPK1/3 activation | Mus musculus |
| NF-kB is activated and signals survival | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111960 | immunodeficiency 15A |
