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ATP-binding cassette sub-family C member 6

Summary

UniProt ID

O95255

Gene Symbol

ABCC6
ARA
MRP6

Gene ID

368

Organism

Homo sapiens (human)

External Links

GlyGen: O95255
PubChem: O95255
The Human Metabolome Database: HMDBP01859
The O-GlcNAc Database: O95255
Re-Glyco: O95255

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Disease variant
Endoplasmic reticulum
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Translocase
Transmembrane helix
Transport
Vision

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
plasma membrane
membrane
nucleoplasm
endoplasmic reticulum membrane
basal plasma membrane
basolateral plasma membrane
extracellular region

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 14 in total

1

2

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GO Term
visual perception
ATP metabolic process
calcium ion homeostasis
transmembrane transport
inhibition of non-skeletal tissue mineralization
gene expression
response to xenobiotic stimulus
inorganic diphosphate transport
intracellular phosphate ion homeostasis
response to magnesium ion

Displaying **all 5** entries
GO Term
ATP binding
ATP hydrolysis activity
ATPase-coupled transmembrane transporter activity
ABC-type glutathione S-conjugate transporter activity
ATPase-coupled inorganic anion transmembrane transporter activity

Annotation information from UniProt.

Sequence

MAAPAEPCAGQGVWNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKMVLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSSGVLFGYWLLCFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQPPFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
15	N-linked (GlcNAc...) asparagine	12901863		UniProt GlyGen
1207			G49108TO	The O-GlcNAc Database
1213			G49108TO	The O-GlcNAc Database
1215			G49108TO	The O-GlcNAc Database

Feature

Domains & sites

PTM

ProtVista

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
ABC-family proteins mediated transport	Homo sapiens
Defective ABCC6 causes PXE	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050644	arterial calcification of infancy	Alliance of Genome Resources
DOID:2738	pseudoxanthoma elasticum	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements