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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Poly [ADP-ribose] polymerase tankyrase-1
Summary
- UniProt ID
- O95271
- Gene Symbol
-
- TNKS
- PARP5A
- PARPL
- TIN1
- TINF1
- TNKS1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O95271
- PubChem
- O95271
- The Human Metabolome Database
- HMDBP00912
- The O-GlcNAc Database
- O95271
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- ANK repeat
- Alternative splicing
- Cytoskeleton
- Glycosyltransferase
- Golgi apparatus
- Membrane
- Metal-binding
- Mitosis
- NAD
- Nuclear pore complex
- Nucleotidyltransferase
- Phosphoprotein
- Reference proteome
- Repeat
- Telomere
- Ubl conjugation
- Wnt signaling pathway
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| nuclear body |
| mitotic spindle pole |
| GO Term |
|---|
| NAD+-protein ADP-ribosyltransferase activity |
| NAD+ ADP-ribosyltransferase activity |
| nucleotidyltransferase activity |
| zinc ion binding |
| histone binding |
Sequence
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Degradation of AXIN | Homo sapiens |
| Regulation of PTEN stability and activity | Homo sapiens |
| TCF dependent signaling in response to WNT | Homo sapiens |
| Ub-specific processing proteases | Homo sapiens |
| XAV939 stabilizes AXIN | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060584 | Noonan syndrome 6 | |
| DOID:0060585 | Noonan syndrome 7 | |
| DOID:0060586 | Noonan syndrome 8 | |
| DOID:0060587 | Noonan syndrome 9 | |
| DOID:0060588 | Noonan syndrome 10 | |
| DOID:0060608 | microcephalic osteodysplastic primordial dwarfism type I | |
| DOID:0060609 | microcephalic osteodysplastic primordial dwarfism type II | |
| DOID:0060644 | chondrodysplasia-pseudohermaphroditism syndrome | |
| DOID:0060764 | autosomal recessive Robinow syndrome | |
| DOID:0060765 | autosomal dominant Robinow syndrome 2 |
