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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Poly [ADP-ribose] polymerase tankyrase-1
Summary
- UniProt ID
- O95271
- Gene Symbol
-
- TNKS
- PARP5A
- PARPL
- TIN1
- TINF1
- TNKS1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- O95271
- PubChem
- O95271
- The Human Metabolome Database
- HMDBP00912
- The O-GlcNAc Database
- O95271
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- ANK repeat
- Alternative splicing
- Cytoskeleton
- Glycosyltransferase
- Golgi apparatus
- Membrane
- Metal-binding
- Mitosis
- NAD
- Nuclear pore complex
- Nucleotidyltransferase
- Phosphoprotein
- Reference proteome
- Repeat
- Telomere
- Ubl conjugation
- Wnt signaling pathway
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| nuclear body |
| mitotic spindle pole |
| GO Term |
|---|
| NAD+-protein ADP-ribosyltransferase activity |
| NAD+ ADP-ribosyltransferase activity |
| nucleotidyltransferase activity |
| zinc ion binding |
| histone binding |
Sequence
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Degradation of AXIN | Homo sapiens |
| Regulation of PTEN stability and activity | Homo sapiens |
| TCF dependent signaling in response to WNT | Homo sapiens |
| Ub-specific processing proteases | Homo sapiens |
| XAV939 stabilizes AXIN | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3868 | melanotic medulloblastoma | |
| DOID:3869 | childhood medulloblastoma | |
| DOID:3892 | insulinoma | |
| DOID:3904 | bronchus carcinoma | |
| DOID:3905 | lung carcinoma | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:3910 | lung adenocarcinoma | |
| DOID:4001 | ovarian carcinoma | |
| DOID:4007 | bladder carcinoma | |
| DOID:4015 | sarcomatoid carcinoma |
