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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
Summary
- UniProt ID
- O95803
- Gene Symbol
-
- NDST3
- HSST3
- Organism
- Homo sapiens (human)
External Links
- The Human Metabolome Database
- HMDBP11855
Annotation
- Keyword
-
- Alternative splicing
- Disulfide bond
- Glycoprotein
- Golgi apparatus
- Hydrolase
- Multifunctional enzyme
- Reference proteome
- Signal-anchor
- Transferase
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| Golgi apparatus |
| GO Term |
|---|
| [heparan sulfate]-glucosamine N-sulfotransferase activity |
| deacetylase activity |
| heparan sulfate N-deacetylase activity |
Sequence
MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELSETASEVDCGDLQHLPYQLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVLIDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGFPFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKTPENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESSLVEQMILNKKFALEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQTCGLFTHTIFYKEYPGGPKELDKSIQGGELFFTVVLNPISIFMTHLSNYGNDRLGLYTFVNLANFVKSWTNLRLQTLPPVQLAHKYFELFPDQKDPLWQNPCDDKRHRDIWSKEKTCDRLPKFLVIGPQKTGTTALYLFLVMHPSILSNSPSPKTFEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYFHSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVISAGPRAPSELRALQKRCLVPGWYASHIERWLVYFPPFQLLIIDGQQLRTDPATVMDEVQKFLGVLPHYNYSEALTFDSHKGFWCQLLEEGKTKCLGKSKGRKYPPMDSDSRTFLSSYYRDHNVELSKLLHKLGQPLPSWLRQELQKVR
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 146 | N-linked (GlcNAc...) asparagine |
|
||
| 226 | N-linked (GlcNAc...) asparagine |
|
||
| 342 | N-linked (GlcNAc...) asparagine |
|
||
| 392 | N-linked (GlcNAc...) asparagine |
|
||
| 658 | N-linked (GlcNAc...) asparagine |
|
||
| 794 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG biosynthesis | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060215 | Balo concentric sclerosis | |
| DOID:10588 | adrenoleukodystrophy | |
| DOID:14320 | generalized anxiety disorder | |
| DOID:1470 | major depressive disorder | |
| DOID:1595 | melancholic depression | |
| DOID:1596 | depressive disorder | |
| DOID:2030 | anxiety disorder | |
| DOID:2848 | obsolete melancholia | |
| DOID:331 | central nervous system disease | |
| DOID:4964 | neurotic disorder |
