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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Purine nucleoside phosphorylase
Summary
- UniProt ID
- P00491
- Gene Symbol
-
- PNP
- NP
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P00491
- PubChem
- P00491
- The Human Metabolome Database
- HMDBP03752
- The O-GlcNAc Database
- P00491
- RaftProt
- P00491
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Glycosyltransferase
- Phosphoprotein
- Purine salvage
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| cytoplasm |
| extracellular exosome |
| secretory granule lumen |
| cytosol |
| ficolin-1-rich granule lumen |
Sequence
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Purine catabolism | Homo sapiens |
| Purine salvage | Homo sapiens |
| Ribavirin ADME | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050127 | sinusitis | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050749 | peripheral T-cell lymphoma | |
| DOID:0060010 | Omenn syndrome | |
| DOID:0060058 | lymphoma | |
| DOID:0080144 | childhood acute lymphocytic leukemia | |
| DOID:0080147 | lymphoblastic lymphoma | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0090103 | Huntington's disease-like 1 |
