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MIRAGE
Complement C3
Summary
- UniProt ID
- P01026
- Gene Symbol
-
- C3
- Gene ID
- 24232
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- 3D-structure
- Chemotaxis
- Cleavage on pair of basic residues
- Complement alternate pathway
- Complement pathway
- Direct protein sequencing
- Disulfide bond
- Fatty acid metabolism
- Glycoprotein
- Inflammatory response
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Thioester bond
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular region |
| extracellular space |
| protein-containing complex |
| cell surface |
| GO Term |
|---|
| C5L2 anaphylatoxin chemotactic receptor binding |
| endopeptidase inhibitor activity |
| lipid binding |
| receptor ligand activity |
Sequence
MGPTSGSQLLVLLLLLASSLLALGSPMYSIITPNVLRLESEETFILEAHDAQGDVPVTVTVQDFLKKQVLTSEKTVLTGATGHLNRVFIKIPASKEFNADKGHKYVTVVANFGATVVEKAVLVSFQSGYLFIQTDKTIYTPGSTVFYRIFTVDNNLLPVGKTVVIVIETPDGVPIKRDILSSHNQYGILPLSWNIPELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTEKFYYIHGPKGLEVSITARFLYGKNVDGTAFVIFGVQDEDKKISLALSLTRVLIEDGSGEAVLSRKVLMDGVRPSSPEALVGKSLYVSVTVILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKFFKPAMPFDLMVFVTNPDGSPARRVPVVTQGSDAQALTQDDGVAKLSVNTPNNRQPLTITVSTKKEGIPDARQATRTMQAQPYSTMHNSNNYLHLSVSRVELKPGDNLNVNFHLRTDAGQEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLPITPEFIPSFRLVAYYTLIGANGQREVVADSVWVDVKDSCVGTLVVKGDPRDNRQPAPGHQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKNYAGVFMDAGLTFKTNQGLQTDQREDPECAKPAARRRRSVQLMERRMDKAGQYTDKGLRKCCEDGMRDIPMPYSCQRRARLITQGESCLKAFMDCCNYITKLREQHRRDHVLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAVSLSDKKGICVADPYEITVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYREQEKLKVRVELLHNPAFCSMATAKKRYYQTIEIPPKSSVAVPYVIVPLKIGLQEVEVKAAVFNHFISDGVKKILKVVPEGMRVNKTVAVRTLDPEHLNQGGVQREDVNAADLSDQVPDTDSETRILLQGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDQTEQWEKFGLEKRQEALELIKKGYTQQLAFKQPISAYAAFNNRPPSTWLTAMWSRSFSLAANLIAIDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAFVLIALQEARDICEGQVNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMNKLEEPYLTKFLNTAKDRNRWEEPGQQLYNVEATSYALLALLLLKDFDSVPPVVRWLNDERYYGGGYGSTQATFMVFQALAQYRADVPDHKDLNMDVSLHLPSRSSPTVFRLLWESGSLLRSEETKQNEGFSLTAKGKGQGTLSVVTVYHAKVKGKTTCKKFDLRVTIKPAPETAKKPQDAKSSMILDICTRYLGDVDATMSILDISMMTGFIPDTNDLELLSSGVDRYISKYEMDKAFSNKNTLIIYLEKISHSEEDCLSFKVHQFFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHNEMCRCAEENCFMHQSQDQVSLNERLDKACEPGVDYVYKTKLTTIELSDDFDEYIMTIEQVIKSGSDEVQAGQERRFISHVKCRNALKLQKGKQYLMWGLSSDLWGEKPNTSYIIGKDTWVEHWPEAEERQDQKNQKQCEDLGAFTETMVVFGCPN
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of C3 and C5 | Rattus norvegicus |
| Alternative complement activation | Rattus norvegicus |
| G alpha (i) signalling events | Rattus norvegicus |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Rattus norvegicus |
| Neutrophil degranulation | Rattus norvegicus |
| Peptide ligand-binding receptors | Rattus norvegicus |
| Post-translational protein phosphorylation | Rattus norvegicus |
| Regulation of Complement cascade | Rattus norvegicus |
| Regulation of IGF Activity by IGFBP | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10591 | pre-eclampsia | |
| DOID:10976 | membranous glomerulonephritis | |
| DOID:2921 | glomerulonephritis | |
| DOID:552 | pneumonia | |
| DOID:9970 | obesity |
