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Beta-nerve growth factor

Summary

UniProt ID

P01138

Gene Symbol

NGF
NGFB

Organism

Homo sapiens (human)

External Links

GlyGen: P01138
PubChem: P01138
The Human Metabolome Database: HMDBP02581

Annotation

Keyword

3D-structure
Cleavage on pair of basic residues
Disease variant
Disulfide bond
Endosome
Glycoprotein
Growth factor
Lipid-binding
Metalloprotease inhibitor
Neurodegeneration
Neuropathy
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 13 in total

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GO Term
nerve growth factor signaling pathway
positive regulation of Ras protein signal transduction
nerve development
negative regulation of cell population proliferation
positive regulation of gene expression
modulation of chemical synaptic transmission
positive regulation of DNA binding
transmembrane receptor protein tyrosine kinase signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of peptidyl-serine phosphorylation

Displaying **all 8** entries
GO Term
synaptic vesicle
endosome lumen
Golgi lumen
cytosol
extracellular region
extracellular space
axon
dendrite

Displaying **all 4** entries
GO Term
nerve growth factor receptor binding
growth factor activity
metalloendopeptidase inhibitor activity
lipid binding

Annotation information from UniProt.

Sequence

MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	GlyTouCan ID	Source
40		G57321FI	GlyGen
43		G57321FI	GlyGen
46		G57321FI	GlyGen
69	N-linked (GlcNAc...) asparagine		UniProt GlyGen
114	N-linked (GlcNAc...) asparagine		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 19 in total

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Pathway Name	Organism
ARMS-mediated activation	Homo sapiens
Axonal growth stimulation	Homo sapiens
Ceramide signalling	Homo sapiens
Frs2-mediated activation	Homo sapiens
NADE modulates death signalling	Homo sapiens
NF-kB is activated and signals survival	Homo sapiens
NFG and proNGF binds to p75NTR	Homo sapiens
NGF processing	Homo sapiens
NRAGE signals death through JNK	Homo sapiens
NRIF signals cell death from the nucleus	Homo sapiens