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H-2 class II histocompatibility antigen, E-D alpha chain

Summary

UniProt ID

P01904

Gene Symbol

H2-Ea

Organism

Mus musculus (house mouse)

External Links

Annotation

Keyword

3D-structure
Disulfide bond
Glycoprotein
MHC II
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
positive regulation of T cell activation
antigen processing and presentation of exogenous peptide antigen via MHC class II
peptide antigen assembly with MHC class II protein complex
immunoglobulin mediated immune response
positive regulation of immune response

Displaying **all 6** entries
GO Term
late endosome membrane
external side of plasma membrane
lysosome
lysosomal membrane
plasma membrane
MHC class II protein complex

Displaying **all 2** entries
GO Term
peptide antigen binding
MHC class II protein complex binding

Annotation information from UniProt.

Sequence

MATIGALVLRFFFIAVLMSSQKSWAIKEEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETIWRLEEFAKFASFEAQGALANIAVDKANLDVMKERSNNTPDANVAPEVTVLSRSPVNLGEPNILICFIDKFSPPVVNVTWLRNGRPVTEGVSETVFLPRDDHLFRKFHYLTFLPSTDDFYDCEVDHWGLEEPLRKTWEFEEKTLLPETKENVMCALGLFVGLVGIVVGIILIMKGIKKRNVVERRQGAL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
143	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Downstream TCR signaling	Mus musculus
Generation of second messenger molecules	Mus musculus
MHC class II antigen presentation	Mus musculus
PD-1 signaling	Mus musculus
Phosphorylation of CD3 and TCR zeta chains	Mus musculus
Translocation of ZAP-70 to Immunological synapse	Mus musculus