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Tyrosine 3-monooxygenase
Summary
- UniProt ID
- P04177
- Gene Symbol
-
- Th
- Gene ID
- 25085
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- 3D-structure
- Catecholamine biosynthesis
- Cell projection
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Iron
- Metal-binding
- Monooxygenase
- Neurotransmitter biosynthesis
- Nucleus
- Phosphoprotein
- Reference proteome
- Synapse
- Gene Ontology (GO)
| GO Term |
|---|
| smooth endoplasmic reticulum |
| nucleus |
| cytoplasm |
| mitochondrion |
| axon |
| dendrite |
| cytoplasmic vesicle membrane |
| cytoplasmic vesicle |
| neuron projection |
| neuronal cell body |
| GO Term |
|---|
| response to hypoxia |
| fatty acid metabolic process |
| sphingolipid metabolic process |
| visual perception |
| memory |
| mating behavior |
| locomotory behavior |
| regulation of heart contraction |
| response to immobilization stress |
| cellular response to manganese ion |
| GO Term |
|---|
| tyrosine 3-monooxygenase activity |
| tetrahydrobiopterin binding |
| dopamine binding |
| monooxygenase activity |
| ferrous iron binding |
| ferric iron binding |
| amino acid binding |
| oxygen binding |
| enzyme binding |
| protein domain specific binding |
Sequence
MPTPSAPSPQPKGFRRAVSEQDAKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAVASSEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRAVKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQDELHTLAHALSAIS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 3 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Catecholamine biosynthesis | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14330 | Parkinson's disease |
