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Proto-oncogene Wnt-1

Summary

UniProt ID

P04628

Gene Symbol

WNT1
INT1

Organism

Homo sapiens (human)

External Links

PubChem: P04628

Annotation

Keyword

Developmental protein
Disease variant
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Osteogenesis imperfecta
Osteoporosis
Proto-oncogene
Reference proteome
Signal
Wnt signaling pathway

Gene Ontology (GO)

Displaying entries **41 - 50** of 51 in total

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GO Term
branching involved in ureteric bud morphogenesis
positive regulation of lamellipodium assembly
negative regulation of cell-substrate adhesion
diencephalon development
forebrain anterior/posterior pattern specification
positive regulation of insulin-like growth factor receptor signaling pathway
fat cell differentiation
positive regulation of DNA-binding transcription factor activity
hepatocyte differentiation
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Displaying **all 9** entries
GO Term
extracellular exosome
endoplasmic reticulum lumen
Golgi lumen
cell surface
extracellular region
extracellular space
cytoplasm
plasma membrane
endocytic vesicle membrane

Displaying **all 5** entries
GO Term
protein domain specific binding
receptor ligand activity
morphogen activity
frizzled binding
cytokine activity

Annotation information from UniProt.

Sequence

MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
29	N-linked (GlcNAc...) asparagine	UniProt
316	N-linked (GlcNAc...) asparagine	UniProt
346	N-linked (GlcNAc...) asparagine	UniProt
359	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Class B/2 (Secretin family receptors)	Homo sapiens
Disassembly of the destruction complex and recruitment of AXIN to the membrane	Homo sapiens
PCP/CE pathway	Homo sapiens
TCF dependent signaling in response to WNT	Homo sapiens
Transcriptional regulation of white adipocyte differentiation	Homo sapiens
WNT ligand biogenesis and trafficking	Homo sapiens