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MIRAGE
High affinity nerve growth factor receptor

Summary
UniProt ID
P04629
Gene Symbol
  • MTC
  • NTRK1
  • TRK
  • TRKA
Gene ID
4914
Organism
Homo sapiens (human)
GlyGen
P04629
PubChem
P04629
The Human Metabolome Database
HMDBP01503
Re-Glyco
P04629
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Alternative splicing
  • Cell membrane
  • Chromosomal rearrangement
  • Developmental protein
  • Differentiation
  • Disease variant
  • Disulfide bond
  • Endosome
  • Glycoprotein
  • Immunoglobulin domain
  • Leucine-rich repeat
  • Neurogenesis
  • Phosphoprotein
  • Proto-oncogene
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
  • Tyrosine-protein kinase
  • Ubl conjugation
Gene Ontology (GO)
Displaying entries 1 - 10 of 14 in total
GO Term
mitochondrion
plasma membrane
axon
dendrite
protein-containing complex
neuronal cell body
receptor complex
early endosome
late endosome
cell surface
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 13 in total
Position Description PubMed ID GlyTouCan ID Source
67 N-linked (GlcNAc...) asparagine
95 N-linked (GlcNAc...) asparagine
121 N-linked (GlcNAc...) asparagine
188 N-linked (GlcNAc...) asparagine
202 N-linked (GlcNAc...) asparagine
253 N-linked (GlcNAc...) asparagine
262 N-linked (GlcNAc...) asparagine
281 N-linked (GlcNAc...) asparagine
318 N-linked (GlcNAc...) asparagine
323 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 9 entries
Pathway Name Organism
ARMS-mediated activation Homo sapiens
NGF-independant TRKA activation Homo sapiens
PI3K/AKT activation Homo sapiens
PLC-gamma1 signalling Homo sapiens
Retrograde neurotrophin signalling Homo sapiens
Signalling to RAS Homo sapiens
Signalling to STAT3 Homo sapiens
Signalling to p38 via RIT and RIN Homo sapiens
TRKA activation by NGF Homo sapiens
Disease
Displaying all 4 entries
DO ID Disease Name Source
DOID:0050548 hereditary sensory neuropathy
DOID:0070146 hereditary sensory neuropathy type 4
DOID:10652 Alzheimer's disease
DOID:5419 schizophrenia
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025