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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Summary
- UniProt ID
- P04843
- Gene Symbol
-
- RPN1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Endoplasmic reticulum
- Glycoprotein
- Isopeptide bond
- Reference proteome
- Signal
- Transmembrane helix
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| protein N-linked glycosylation via asparagine |
| protein N-linked glycosylation |
| GO Term |
|---|
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| rough endoplasmic reticulum |
| oligosaccharyltransferase complex |
| membrane |
| melanosome |
| cytosol |
| GO Term |
|---|
| RNA binding |
Sequence
MEAPAAGLFLLLLLGTWAPAPGSASSEAPPLINEDVKRTVDLSSHLAKVTAEVVLAHLGGGSTSRATSFLLALEPELEARLAHLGVQVKGEDEEENNLEVRETKIKGKSGRFFTVKLPVALDPGAKISVIVETVYTHVLHPYPTQITQSEKQFVVFEGNHYFYSPYPTKTQTMRVKLASRNVESYTKLGNPTRSEDLLDYGPFRDVPAYSQDTFKVHYENNSPFLTITSMTRVIEVSHWGNIAVEENVDLKHTGAVLKGPFSRYDYQRQPDSGISSIRSFKTILPAAAQDVYYRDEIGNVSTSHLLILDDSVEMEIRPRFPLFGGWKTHYIVGYNLPSYEYLYNLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIEIDSPYEISRAPDELHYTYLDTFGRPVIVAYKKNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYILFFTVIIYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRIGLYRHFDETVNRYKQSRDISTLNSGKKSLETEHKALTSEIALLQSRLKTEGSDLCDRVSEMQKLDAQVKELVLKSAVEAERLVAGKLKKDTYIENEKLISGKRQELVTKIDHILDAL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 39 |
|
|||
| 50 |
|
|||
| 62 |
|
|||
| 64 |
|
|||
| 144 |
|
|||
| 220 |
|
|||
| 228 |
|
|||
| 237 |
|
|||
| 282 |
|
|||
| 299 | N-linked (GlcNAc...) asparagine |
G57321FI
G60033FS
G92406TI
G90659AW
G37399XV
G47644PP
G11314AS
G41247ZX
G50282JC
G35029YA
G49108TO
G40926MX
G72747WU
G48584BU
G70101JE
G05049YU
G46687AB
G05724UK
G31852PQ
G39188ZX
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Asparagine N-linked glycosylation | Homo sapiens |
| Maturation of spike protein | Homo sapiens |
| SRP-dependent cotranslational protein targeting to membrane | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1240 | leukemia | |
| DOID:13739 | nutmeg liver | |
| DOID:1936 | atherosclerosis | |
| DOID:2348 | arteriosclerotic cardiovascular disease | |
| DOID:3393 | coronary artery disease | |
| DOID:7757 | childhood leukemia | |
| DOID:784 | chronic kidney disease | |
| DOID:8584 | Burkitt lymphoma | |
| DOID:9119 | acute myeloid leukemia |
