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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Steroid 17-alpha-hydroxylase/17,20 lyase
Summary
- UniProt ID
- P05093
- Gene Symbol
-
- CYP17A1
- CYP17
- S17AH
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P05093
- PubChem
- P05093
- SwissLipids
- The Human Metabolome Database
- HMDBP01043
- The O-GlcNAc Database
- P05093
Annotation
- Keyword
-
- 3D-structure
- Congenital adrenal hyperplasia
- Disease variant
- Heme
- Lipid metabolism
- Lyase
- Membrane
- Microsome
- Monooxygenase
- Phosphoprotein
- Reference proteome
- Steroidogenesis
- Gene Ontology (GO)
| GO Term |
|---|
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| axon |
| neuronal cell body |
| GO Term |
|---|
| iron ion binding |
| oxygen binding |
| heme binding |
| 17-alpha-hydroxyprogesterone aldolase activity |
| steroid 17-alpha-monooxygenase activity |
Sequence
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Androgen biosynthesis | Homo sapiens |
| Defective CYP17A1 causes AH5 | Homo sapiens |
| Glucocorticoid biosynthesis | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050457 | Sertoli cell-only syndrome | |
| DOID:0050477 | Liddle syndrome | |
| DOID:0050745 | diffuse large B-cell lymphoma | |
| DOID:0050782 | Zollinger-Ellison syndrome | |
| DOID:0050801 | androgenic alopecia | |
| DOID:0050811 | congenital adrenal hyperplasia | |
| DOID:0060058 | lymphoma | |
| DOID:0060060 | non-Hodgkin lymphoma | |
| DOID:0060262 | gallbladder disease | |
| DOID:0060870 | isolated growth hormone deficiency |
