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T-cell surface glycoprotein CD4

Summary

UniProt ID

P06332

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

PubChem: P06332

Annotation

Keyword

Adaptive immunity
Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 23 in total

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GO Term
positive regulation of ERK1 and ERK2 cascade
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of T cell proliferation
positive regulation of monocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of calcium-mediated signaling
positive regulation of T cell activation
maintenance of protein location in cell
positive regulation of viral entry into host cell
positive regulation of canonical NF-kappaB signal transduction

Displaying **all 6** entries
GO Term
plasma membrane
membrane raft
endoplasmic reticulum membrane
endoplasmic reticulum lumen
external side of plasma membrane
cell surface

Displaying entries **1 - 10** of 11 in total

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GO Term
protein tyrosine kinase binding
protein homodimerization activity
immunoglobulin binding
zinc ion binding
coreceptor activity
interleukin-16 binding
interleukin-16 receptor activity
MHC class II protein binding
signaling receptor binding
protein kinase binding

Annotation information from UniProt.

Sequence

MCRAISLRRLLLLLLQLSQLLAVTQGKTLVLGKEGESAELPCESSQKKITVFTWKFSDQRKILGQHGKGVLIRGGSPSQFDRFDSKKGAWEKGSFPLIINKLKMEDSQTYICELENRKEEVELWVFKVTFSPGTSLLQGQSLTLTLDSNSKVSNPLTECKHKKGKVVSGSKVLSMSNLRVQDSDFWNCTVTLDQKKNWFGMTLSVLGFQSTAITAYKSEGESAEFSFPLNFAEENGWGELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQLKETLPLTLKIPQVSLQFAGSGNLTLTLDKGTLHQEVNLVVMKVAQLNNTLTCEVMGPTSPKMRLTLKQENQEARVSEEQKVVQVVAPETGLWQCLLSEGDKVKMDSRIQVLSRGVNQTVFLACVLGGSFGFLGFLGLCILCCVRCRHQQRQAARMSQIKRLLSEKKTCQCPHRMQKSHNLI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
187	N-linked (GlcNAc...) asparagine	UniProt
298	N-linked (GlcNAc...) asparagine	UniProt
323	N-linked (GlcNAc...) asparagine	UniProt
392	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Alpha-defensins	Mus musculus
Cargo recognition for clathrin-mediated endocytosis	Mus musculus
Clathrin-mediated endocytosis	Mus musculus
Downstream TCR signaling	Mus musculus
Generation of second messenger molecules	Mus musculus
Other interleukin signaling	Mus musculus
PD-1 signaling	Mus musculus
Phosphorylation of CD3 and TCR zeta chains	Mus musculus
Translocation of ZAP-70 to Immunological synapse	Mus musculus