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MIRAGE
Lipoprotein lipase

Summary
UniProt ID
P06858
Gene Symbol
  • LIPD
  • LPL
Gene ID
4023
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P06858
PubChem
P06858
SwissLipids
The Human Metabolome Database
HMDBP00310
Re-Glyco
P06858
Annotation
Keyword
  • 3D-structure
  • Calcium
  • Cell membrane
  • Chylomicron
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Extracellular matrix
  • Glycoprotein
  • Heparin-binding
  • Hydrolase
  • Hyperlipidemia
  • Lipid degradation
  • Metal-binding
  • Nitration
  • Reference proteome
  • Signal
  • VLDL
Gene Ontology (GO)
Displaying all 7 entries
GO Term
catalytic complex
extracellular region
extracellular space
plasma membrane
chylomicron
cell surface
very-low-density lipoprotein particle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
70 N-linked (GlcNAc...) asparagine
386 N-linked (GlcNAc...) asparagine
417
Feature
501001502002503003504004501475
50100150200250300350400450MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
Domains & sites
PTM
ProtVista
50100150200250300350400450MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 5 entries
Pathway Name Organism
Assembly of active LPL and LIPC lipase complexes Homo sapiens
Chylomicron remodeling Homo sapiens
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Homo sapiens
Retinoid metabolism and transport Homo sapiens
Transcriptional regulation of white adipocyte differentiation Homo sapiens
Disease
Displaying all 9 entries
DO ID Disease Name Source
DOID:0080000 muscular disease
DOID:10652 Alzheimer's disease
DOID:10763 hypertension
DOID:1168 familial hyperlipidemia
DOID:13809 familial combined hyperlipidemia
DOID:14118 familial lipoprotein lipase deficiency
DOID:3393 coronary artery disease
DOID:5844 myocardial infarction
DOID:9352 type 2 diabetes mellitus
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025