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Pro-epidermal growth factor

Summary

UniProt ID

P07522

Gene Symbol

Gene ID

25313

Organism

Rattus norvegicus (Norway rat)

External Links

Re-Glyco: P07522

Annotation

Keyword

Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 3** entries
GO Term
extracellular space
plasma membrane
extracellular exosome

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
positive regulation of ubiquitin-dependent protein catabolic process
kidney development
positive regulation of endothelial cell proliferation
positive regulation of receptor internalization
positive regulation of MAPK cascade
positive regulation of fibroblast proliferation
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
cell population proliferation
positive regulation of cell population proliferation
positive regulation of gene expression

Displaying **all 6** entries
GO Term
guanyl-nucleotide exchange factor activity
growth factor activity
epidermal growth factor receptor binding
receptor ligand activity
calcium ion binding
transmembrane receptor protein tyrosine kinase activator activity

Annotation information from UniProt.

Sequence

MLFSLTFLSVFLKITVLSVTAQQTRNCQSGPLERSGTTTYAAAGPPRFLIFLQGNSIFRINTDGTNHQQLVVDAGVSVVMDFHYKEERLYWVDLERQLLQRVFFNGSGQETVCKVDKNVSGLAINWIDGEILRTDRWKGVITVTDMNGNNSRVLLSSLKRPANILVDPTERLIFWSSVVTGNLHRADLGGMDVKTLLEAPERISVLILDILDKRLFWAQDGREGSHGYIHSCDYNGGSIHHIRHQARHDLLTMAIFGDKILYSALKEKAIWIADKHTGKNVVRVNLDPASVPPRELRVVHLHAQPGTENRAQASDSERCKQRRGQCLYSLSERDPNSDSSACAEGYTLSRDRKYCEDVNECALQNHGCTLGCENIPGSYYCTCPTGFVLLPDGKRCHELVACPGNRSECSHDCILTSDGPLCICPAGSVLGKDGKTCTGCSFSDNGGCSQICLPLSLASWECDCFPGYDLQLDRKSCAASMGPQPFLLFANSQDIRHMHFDGTDYKTLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANLDGSQRERRITEGVDTPEGLAVDWIGRRIYWTDSGKSVIEGSDLSGKHHQIIIKESISRPRGIAVHPKARRLFWTDTGMSPRIESSSLQGSDRTLIASSNLLEPSGIAIDYLTDTLYWCDTKLSVIEMADLDGSKRRRLTQNDVGHPFSLAVFEDHVWFSDWAIPSVIRVNKRTGQNRVRLRGSMLKPSSLVVVHPLAKPGADPCLHRNGGCEHICQESLGTAQCLCREGFVKAPDGKMCLTRKDDQILAGDNADLSKEVASLDNSPKAYVPDDDRTESSTLVAEIMVSGLNYEDDCGPGGCGSHAHCISEGEAAVCQCLKGFAGDGNLCSDIDECELGSSDCPPTSSRCINTEGGYVCQCSEGYEGDGIYCLDVDECQQGSHGCSENATCTNTEGGYNCTCAGCPSAPGLPCPDSTSPSLLGKDGCHWVRNSNTGCPPSYDGYCLNGGVCMYVESVDRYVCNCVIGYIGERCQHRDLRWWKLRHADYGQRHDITVVSVCVVALALLLLLGMWGTYYYRTRKQLSESSKKPSEESSSNVSSNGPDSSGAGVSSGPQPWFVVLEEHQQPKNGRLPAAGTNGAVVEAGLSSSL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	Source
105	N-linked (GlcNAc...) asparagine	UniProt
118	N-linked (GlcNAc...) asparagine	UniProt
149	N-linked (GlcNAc...) asparagine	UniProt
405	N-linked (GlcNAc...) asparagine	UniProt
930	N-linked (GlcNAc...) asparagine	UniProt
941	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Cargo recognition for clathrin-mediated endocytosis	Rattus norvegicus
Clathrin-mediated endocytosis	Rattus norvegicus
Downregulation of ERBB2 signaling	Rattus norvegicus
EGFR downregulation	Rattus norvegicus
EGFR interacts with phospholipase C-gamma	Rattus norvegicus
ERBB2 Activates PTK6 Signaling	Rattus norvegicus
ERBB2 Regulates Cell Motility	Rattus norvegicus
Extra-nuclear estrogen signaling	Rattus norvegicus
GAB1 signalosome	Rattus norvegicus
GRB2 events in EGFR signaling	Rattus norvegicus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:8677	perinatal necrotizing enterocolitis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Annotation

International Collaboration

Acknowledgements