GlyCosmos Portal

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Decorin

Summary

UniProt ID

P07585

Gene Symbol

DCN
SLRR1B

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0015592

GlyConnect

1169

GlyGen

P07585

PubChem

P07585

RaftProt

P07585

Annotation

Keyword

Alternative splicing
Corneal dystrophy
Direct protein sequencing
Disulfide bond
Extracellular matrix
Leucine-rich repeat
Proteoglycan
Reference proteome
Repeat
Signal

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
animal organ morphogenesis
positive regulation of autophagy
negative regulation of endothelial cell migration
positive regulation of macroautophagy
negative regulation of angiogenesis
positive regulation of mitochondrial fission
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of mitochondrial depolarization
positive regulation of transcription by RNA polymerase II

Displaying **all 5** entries
GO Term
Golgi lumen
lysosomal lumen
extracellular region
extracellular space
collagen-containing extracellular matrix

Displaying **all 4** entries
GO Term
RNA binding
glycosaminoglycan binding
extracellular matrix binding
extracellular matrix structural constituent conferring compression resistance

Annotation information from UniProt.

Sequence

MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 7** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
34	O-linked (Xyl...) (glycosaminoglycan) serine	25326458 32337544 36213313 37453717		UniProt GlyGen
115				GlyGen
211	N-linked (GlcNAc...) asparagine	19159218	G13191RB G55132BD G37818NZ G70888PK G06247RL G13131HA G99668VU G77669RF G86880BF G27947YN G52527GH G24084IV G40206WX G04854VP G94470IW G79666IR G40834TG G45395BF G59324HL G85554PZ G10819WX G40926MX G59536GA G56307ZW G58954YZ G95977AE G37412TK G31986NC G26330YA G10846ZT G40574BA G82830MN G78787DI G08918WF G75983OB G00912UN G48414YA G11911BT G92551JA G61256FT G83646BJ G17208MA G76295SF G46691LC G25418HZ G27126ED G04657PL G25451PN G27058EU G84452RH G24528MX G37509XX G70223PD G10488MI G20425TQ G60033FS G41071NU G70418MS G24835MQ G86182NS G49018RC G35253PZ G46902YN G72747WU G44215PV G70619PT G06356OH G59626AS G73430PD G47448YK G14994KB G92406TI G41840AI G01650EU G23294PN G80920RR G01485JJ G73968GN G65184UU G42124LM G02886BB G23863VK G90659AW G77547TA G31916IQ G45504EY G80333GO G59924QI G84820NF G12313PD G29299MO G37399XV G82463GQ G83633GK G62765YT G47644PP G23432EQ G72790NZ G10256JP G95177YH G10486CT G50045TK G05049YU G46687AB G28541PG G72735IY G18647XP G82119TF G55383ZG G85269DF G72291OX G95865ZB G05724UK G31852PQ G49955PK G72787SB G81295CK G23719VF G33609NS G39446WN G11314AS G39188ZX G41247ZX G23453IV G57776ZU G02815KT G06110VR G57317CE G60145BJ G92050GC G54010QB	UniProt GlyGen GlyConnect
255				GlyGen
262	N-linked (GlcNAc...) asparagine	19159218	G07810QS G15169WU G70232NH G03644CB G35541EV G34617SM G93718GY G80075MS G11629QQ G57776ZS G75418YA G77669RF G86795LJ G86880BF G52527GH G90382BL G90093AU G40206WX G20528HD G24954UD G63980BQ G04854VP G94470IW G87123QX G79666IR G81263BG G92135MA G26403SG G34989PA G81198YO G40834TG G22310AV G45395BF G59324HL G07246CJ G85554PZ G20706XG G10819WX G14972EH G02030ZB G43223CG G10846ZT G40574BA G82830MN G08918WF G75983OB G00912UN G48414YA G27915IV G87389XI G23505EP G61256FT G70441OD G72797UR G70822IO G87661QW G66760KM G83646BJ G17208MA G63381RX G72667IM G76295SF G46691LC G80223IX G25418HZ G27126ED G04657PL G25451PN G27058EU G84452RH G46524LG G85582CB G96091TT G51640FO G10488MI G41071NU G91636VS G07755XJ G24835MQ G86182NS G35253PZ G44215PV G70619PT G06356OH G59626AS G84862VB G08290VR G14994KB G92406TI G46503DX G20210JR G80920RR G63041LO G01485JJ G50757KG G73968GN G65184UU G03382KH G42124LM G29879MS G65092SV G23863VK G90659AW G77547TA G45504EY G64409MC G62765YT G47950XN G11870QZ G47644PP G72790NZ G10256JP G95177YH G05049YU G46687AB G90734RJ G95865ZB G23719VF G49874UX G11314AS G57776ZU G36379GD G37995HC	GlycoProtDB UniProt GlyGen GlyConnect
303	N-linked (GlcNAc...) asparagine		G64394MX G12341GU G15169WU G70232NH G80075MS G11629QQ G57776ZS G75418YA G77669RF G28622IK G94470IW G81263BG G81198YO G43669FQ G22310AV G45395BF G59324HL G20706XG G02030ZB G43223CG G04657PL G25451PN G27058EU G84452RH G10488MI G01485JJ G23863VK G65000LJ G64409MC	UniProt GlyGen GlyConnect
				GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 12 in total

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Pathway Name	Organism
A tetrasaccharide linker sequence is required for GAG synthesis	Homo sapiens
CS/DS degradation	Homo sapiens
Chondroitin sulfate biosynthesis	Homo sapiens
Defective B3GALT6 causes EDSP2 and SEMDJL1	Homo sapiens
Defective B3GAT3 causes JDSSDHD	Homo sapiens
Defective B4GALT7 causes EDS, progeroid type	Homo sapiens
Defective CHST14 causes EDS, musculocontractural type	Homo sapiens
Defective CHST3 causes SEDCJD	Homo sapiens
Defective CHSY1 causes TPBS	Homo sapiens
Degradation of the extracellular matrix	Homo sapiens

Human Protein Atlas

ENSG00000011465

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **231 - 240** of **403** in total

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DO ID	Disease Name	Source
DOID:1612	breast cancer	DisGeNET DisGeNET DisGeNET
DOID:1618	breast fibroadenoma	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET DisGeNET
DOID:1631	benign breast phyllodes tumor	DisGeNET
DOID:1678	chronic interstitial cystitis	DisGeNET
DOID:1703	Richter's syndrome	DisGeNET
DOID:1749	squamous cell carcinoma	DisGeNET
DOID:175	vascular cancer	DisGeNET
DOID:178	vascular disease	DisGeNET
DOID:1781	thyroid cancer	DisGeNET DisGeNET

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