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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Adenine phosphoribosyltransferase
Summary
- UniProt ID
- P07741
- Gene Symbol
-
- APRT
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P07741
- PubChem
- P07741
- The Human Metabolome Database
- HMDBP00438
- The O-GlcNAc Database
- P07741
- RaftProt
- P07741
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Glycosyltransferase
- Phosphoprotein
- Purine salvage
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| AMP salvage |
| purine ribonucleoside salvage |
| adenine salvage |
| grooming behavior |
| GMP salvage |
| IMP salvage |
| GO Term |
|---|
| extracellular region |
| cytoplasm |
| extracellular exosome |
| secretory granule lumen |
| cytosol |
| nucleoplasm |
| GO Term |
|---|
| adenine binding |
| adenine phosphoribosyltransferase activity |
| AMP binding |
Sequence
MADSELQLVEQRIRSFPDFPTPGVVFRDISPVLKDPASFRAAIGLLARHLKATHGGRIDYIAGLDSRGFLFGPSLAQELGLGCVLIRKRGKLPGPTLWASYSLEYGKAELEIQKDALEPGQRVVVVDDLLATGGTMNAACELLGRLQAEVLECVSLVELTSLKGREKLAPVPFFSLLQYE
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective APRT disrupts adenine salvage | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Purine salvage | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080053 | Albright's hereditary osteodystrophy | |
| DOID:0080070 | mucolipidosis II alpha/beta | |
| DOID:0080092 | myofibrillar myopathy 1 | |
| DOID:0080094 | myofibrillar myopathy 3 | |
| DOID:0080144 | childhood acute lymphocytic leukemia | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:0080324 | tuberous sclerosis 1 | |
| DOID:0080326 | familial hypertrophic cardiomyopathy | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0090053 | episodic kinesigenic dyskinesia 1 |
