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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Beta-glucuronidase
Summary
- UniProt ID
- P08236
- Gene Symbol
-
- GUSB
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Glycosidase
- Lysosome
- Mucopolysaccharidosis
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| carbohydrate binding |
| protein domain specific binding |
| beta-glucuronidase activity |
| signaling receptor binding |
Sequence
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 173 | N-linked (GlcNAc...) asparagine | |||
| 174 |
|
|
||
| 272 | N-linked (GlcNAc...) asparagine | |||
| 274 |
|
|||
| 276 |
|
|||
| 420 |
|
|||
| 631 | N-linked (GlcNAc...) asparagine | |||
|
|
|
G60834IK
G96430BV
G15664MX
G46524LG
G39619TI
G83460ZZ
G72747WU
G47448YK
G84862VB
G08290VR
G46503DX
G25079LO
G48584BU
G70101JE
G80920RR
G06231AO
G92062TF
G45504EY
G65000LJ
G83633GK
G62765YT
G64527OM
G31852PQ
G41247ZX
G70441OD
G51653BI
G90575OW
G50282JC
G02815KT
G84349RE
G92050GC
G74724QE
G92275SC
G28681TP
G49108TO
G39188ZX
G06110VR
G58001LT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG degradation | Homo sapiens |
| Hyaluronan uptake and degradation | Homo sapiens |
| MPS VII - Sly syndrome | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:4195 | hyperglycemia | |
| DOID:420 | hypertrichosis | |
| DOID:4465 | papillary renal cell carcinoma | |
| DOID:4480 | achondroplasia | |
| DOID:4766 | embryoma | |
| DOID:4905 | pancreatic carcinoma | |
| DOID:4960 | bone marrow cancer | |
| DOID:4976 | elephantiasis | |
| DOID:4977 | lymphedema | |
| DOID:5295 | intestinal disease |
