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Neprilysin

Summary

UniProt ID

P08473

Gene Symbol

Organism

Homo sapiens (human)

External Links

GlyConnect

1541

GlyGen

P08473

PubChem

P08473

The Human Metabolome Database

HMDBP02539

RaftProt

P08473

Annotation

Keyword

3D-structure
Cell membrane
Charcot-Marie-Tooth disease
Disease variant
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Myristate
Phosphoprotein
Reference proteome
Signal-anchor
Spinocerebellar ataxia
Transmembrane helix
Zinc

Gene Ontology (GO)

Displaying entries **1 - 10** of 24 in total

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GO Term
substance P catabolic process
bradykinin catabolic process
creatinine metabolic process
amyloid-beta metabolic process
cellular response to UV-A
cellular response to UV-B
replicative senescence
amyloid-beta clearance
amyloid-beta clearance by cellular catabolic process
positive regulation of long-term synaptic potentiation

Displaying entries **1 - 10** of 19 in total

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GO Term
cytoplasm
plasma membrane
membrane
axon
secretory granule membrane
cytoplasmic vesicle
synapse
presynapse
dendrite
neuronal cell body

Displaying **all 9** entries
GO Term
peptide binding
zinc ion binding
oligopeptidase activity
cardiolipin binding
protein homodimerization activity
endopeptidase activity
exopeptidase activity
phosphatidylserine binding
metalloendopeptidase activity

Annotation information from UniProt.

Sequence

MGKSESQMDITDINTPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
145	N-linked (GlcNAc...) asparagine	10669592 12754519 14747736 17704566	G37818NZ G44753VC G68490OW G30970QQ G80479JV G85282JO G20528HD G87123QX G43734MM G02528FI G43669FQ G07246CJ G85554PZ G10819WX G40926MX G26330YA G00912UN G49906RN G27915IV G70441OD G87661QW G83646BJ G76295SF G27058EU G24528MX G43769HG G83460ZZ G37509XX G70223PD G60033FS G41071NU G86182NS G70619PT G59626AS G08290VR G25079LO G80920RR G73968GN G65184UU G42124LM G90659AW G64409MC G83633GK G62765YT G72790NZ G10486CT G50045TK G05049YU G95865ZB G31852PQ G49955PK G72787SB G11314AS G35029YA G57776ZU G02815KT G57317CE G28681TP G37995HC G84225JN	UniProt GlyGen GlyConnect
285	N-linked (GlcNAc...) asparagine	12754519	G13191RB G53075ES G11115RO G81637OR G99679NM G39471UU G05962QB G55132BD G69521XL G35541EV G93718GY G13131HA G49755GI G80075MS G16125XL G29545VG G44753VC G68490OW G60834IK G86880BF G27947YN G28622IK G30970QQ G80479JV G85282JO G87123QX G79666IR G92135MA G98611JV G02528FI G43669FQ G45395BF G07246CJ G85554PZ G10819WX G40926MX G14972EH G43223CG G00273SJ G08918WF G00912UN G49906RN G58087IP G27915IV G70441OD G87661QW G83646BJ G04657PL G27058EU G43769HG G83460ZZ G60033FS G41071NU G07755XJ G86182NS G70619PT G59626AS G80920RR G73968GN G65184UU G42124LM G90659AW G77547TA G62765YT G72790NZ G10486CT G05049YU G72787SB G02815KT G92275SC G28681TP	UniProt GlyGen
294				GlyGen
325	N-linked (GlcNAc...) asparagine	10669592 14747736 17704566		UniProt GlyGen
628	N-linked (GlcNAc...) asparagine	10669592 14747736 17704566 22766194		UniProt GlyGen
681				GlyGen