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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Amyloid-beta precursor protein
Summary
- UniProt ID
- P08592
- Gene Symbol
-
- App
- A4
- AD1
- Organism
- Rattus norvegicus (Norway rat)
External Links
- PubChem
- P08592
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Amyloid
- Apoptosis
- Cell adhesion
- Cell membrane
- Cell projection
- Coated pit
- Copper
- Cytoplasm
- Cytoplasmic vesicle
- Direct protein sequencing
- Disulfide bond
- Endocytosis
- Endoplasmic reticulum
- Endosome
- Golgi apparatus
- Heparin-binding
- Iron
- Isopeptide bond
- Metal-binding
- Notch signaling pathway
- Nucleus
- Phosphoprotein
- Proteoglycan
- Reference proteome
- Secreted
- Serine protease inhibitor
- Signal
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| endosome to plasma membrane transport vesicle |
| amyloid-beta complex |
| growth cone lamellipodium |
| growth cone filopodium |
| clathrin-coated pit |
| synaptic vesicle |
| presynaptic active zone |
| endosome |
| early endosome |
| endoplasmic reticulum |
| GO Term |
|---|
| apolipoprotein binding |
| identical protein binding |
| heparan sulfate proteoglycan binding |
| transition metal ion binding |
| receptor ligand activity |
| low-density lipoprotein particle receptor binding |
| signaling receptor binding |
| heparin binding |
Sequence
MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSIDSADAEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEEEAEDDEDVEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVSSQSLLKTTSEPLPQDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| TAK1-dependent IKK and NF-kappa-B activation | Rattus norvegicus |
| TRAF6 mediated NF-kB activation | Rattus norvegicus |
