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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Poly [ADP-ribose] polymerase 1
Summary
- UniProt ID
- P09874
- Gene Symbol
-
- PARP1
- ADPRT
- PPOL
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P09874
- PubChem
- P09874
- The Human Metabolome Database
- HMDBP00913
- The O-GlcNAc Database
- P09874
- RaftProt
- P09874
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- Acetylation
- Allosteric enzyme
- Apoptosis
- Chromosome
- Cytoplasm
- DNA repair
- DNA-binding
- Direct protein sequencing
- Glycosyltransferase
- Innate immunity
- Isopeptide bond
- NAD
- Nucleotidyltransferase
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Transcription regulation
- Ubl conjugation
- Zinc-finger
- Gene Ontology (GO)
| GO Term |
|---|
| nuclear replication fork |
| chromosome, telomeric region |
| mitochondrion |
| cytosol |
| nucleoplasm |
| transcription regulator complex |
| protein-DNA complex |
| nuclear body |
| site of double-strand break |
| site of DNA damage |
| GO Term |
|---|
| damaged DNA binding |
| NAD+ ADP-ribosyltransferase activity |
| nucleotidyltransferase activity |
| zinc ion binding |
| DNA binding |
| chromatin binding |
| RNA binding |
| enzyme binding |
| protein kinase binding |
Sequence
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| DNA Damage Recognition in GG-NER | Homo sapiens |
| Downregulation of SMAD2/3:SMAD4 transcriptional activity | Homo sapiens |
| Dual Incision in GG-NER | Homo sapiens |
| Formation of Incision Complex in GG-NER | Homo sapiens |
| HDR through MMEJ (alt-NHEJ) | Homo sapiens |
| POLB-Dependent Long Patch Base Excision Repair | Homo sapiens |
| SUMOylation of DNA damage response and repair proteins | Homo sapiens |
| vRNA Synthesis | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110293 | autosomal recessive limb-girdle muscular dystrophy type 2P | |
| DOID:0110294 | autosomal recessive limb-girdle muscular dystrophy type 2T | |
| DOID:0110295 | autosomal recessive limb-girdle muscular dystrophy type 2U | |
| DOID:0110296 | autosomal recessive limb-girdle muscular dystrophy type 2M | |
| DOID:0110297 | autosomal recessive limb-girdle muscular dystrophy type 2K | |
| DOID:0110298 | autosomal recessive limb-girdle muscular dystrophy type 2N | |
| DOID:0110299 | autosomal recessive limb-girdle muscular dystrophy type 2I | |
| DOID:0110300 | obsolete autosomal dominant limb-girdle muscular dystrophy type 1A | |
| DOID:0110301 | obsolete autosomal dominant limb-girdle muscular dystrophy type 1B | |
| DOID:0110302 | obsolete autosomal dominant limb-girdle muscular dystrophy type 1C |
