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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Summary
- UniProt ID
- P10515
- Gene Symbol
-
- DLAT
- DLTA
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P10515
- PubChem
- P10515
- The Human Metabolome Database
- HMDBP00055
- The O-GlcNAc Database
- P10515
- RaftProt
- P10515
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Acyltransferase
- Glucose metabolism
- Lipoyl
- Mitochondrion
- Phosphoprotein
- Reference proteome
- Repeat
- Transit peptide
- Tricarboxylic acid cycle
- Gene Ontology (GO)
| GO Term |
|---|
| glucose metabolic process |
| tricarboxylic acid cycle |
| acetyl-CoA biosynthetic process from pyruvate |
| GO Term |
|---|
| intracellular membrane-bounded organelle |
| mitochondrion |
| mitochondrial matrix |
| mitochondrial pyruvate dehydrogenase complex |
| pyruvate dehydrogenase complex |
| GO Term |
|---|
| identical protein binding |
| dihydrolipoyllysine-residue acetyltransferase activity |
Sequence
MWRVCARRAQNVAPWAGLEARWTALQEVPGTPRVTSRSGPAPARRNSVTTGYGGVRALCGWTPSSGATPRNRLLLQLLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGDKINEGDLIAEVETDKATVGFESLEECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYTLDSSAAPTPQAAPAPTPAATASPPTPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADYRPTEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSAPCPATPAGPKGRVFVSPLAKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIANDVVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPADNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKPITMLL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| PDH complex synthesizes acetyl-CoA from PYR | Homo sapiens |
| Protein lipoylation | Homo sapiens |
| Regulation of pyruvate dehydrogenase (PDH) complex | Homo sapiens |
| Signaling by Retinoic Acid | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050167 | autoimmune polyendocrine syndrome type 1 | |
| DOID:0050841 | focal hand dystonia | |
| DOID:0060216 | Cogan syndrome | |
| DOID:0060260 | ptosis | |
| DOID:0060261 | congenital ptosis | |
| DOID:0060262 | gallbladder disease | |
| DOID:0060643 | primary sclerosing cholangitis | |
| DOID:0110741 | type 1 diabetes mellitus 2 | |
| DOID:0110742 | type 1 diabetes mellitus 3 | |
| DOID:0110743 | type 1 diabetes mellitus 4 |
