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Guanine nucleotide-exchange factor SEC12
Summary
- UniProt ID
- P11655
- Gene Symbol
-
- N3244
- SEC12
- SED2
- YNR026C
- Gene ID
- 855760
- Organism
- Saccharomyces cerevisiae S288C
Annotation
- Keyword
-
- 3D-structure
- ER-Golgi transport
- Endoplasmic reticulum
- GTPase activation
- Glycoprotein
- Golgi apparatus
- Protein transport
- Reference proteome
- Repeat
- Signal-anchor
- Transmembrane helix
- WD repeat
- Gene Ontology (GO)
| GO Term |
|---|
| endoplasmic reticulum |
| endoplasmic reticulum membrane |
| Golgi apparatus |
| GO Term |
|---|
| protein transport |
| regulation of COPII vesicle coating |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO Term |
|---|
| guanyl-nucleotide exchange factor activity |
| GTPase activator activity |
Sequence
MKFVTASYNVGYPAYGAKFLNNDTLLVAGGGGEGNNGIPNKLTVLRVDPTKDTEKEQFHILSEFALEDNDDSPTAIDASKGIILVGCNENSTKITQGKGNKHLRKFKYDKVNDQLEFLTSVDFDASTNADDYTKLVYISREGTVAAIASSKVPAIMRIIDPSDLTEKFEIETRGEVKDLHFSTDGKVVAYITGSSLEVISTVTGSCIARKTDFDKNWSLSKINFIADDTVLIAASLKKGKGIVLTKISIKSGNTSVLRSKQVTNRFKGITSMDVDMKGELAVLASNDNSIALVKLKDLSMSKIFKQAHSFAITEVTISPDSTYVASVSAANTIHIIKLPLNYANYTSMKQKISKFFTNFILIVLLSYILQFSYKHNLHSMLFNYAKDNFLTKRDTISSPYVVDEDLHQTTLFGNHGTKTSVPSVDSIKVHGVHETSSVNGTEVLCTESNIINTGGAEFEITNATFREIDDA
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| COPII-mediated vesicle transport | Saccharomyces cerevisiae |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050577 | cranioectodermal dysplasia | |
| DOID:0060041 | autism spectrum disorder | |
| DOID:1059 | intellectual disability |
