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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Angiotensin-converting enzyme
Summary
- UniProt ID
- P12821
- Gene Symbol
-
- ACE
- DCP
- DCP1
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P12821
- PubChem
- P12821
- The Human Metabolome Database
- HMDBP01710
Annotation
- Keyword
-
- 3D-structure
- Alternative promoter usage
- Alternative splicing
- Calmodulin-binding
- Carboxypeptidase
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| response to dexamethasone |
| cell proliferation in bone marrow |
| regulation of heart rate by cardiac conduction |
| negative regulation of calcium ion import |
| response to thyroid hormone |
| negative regulation of gap junction assembly |
| GO Term |
|---|
| endopeptidase activity |
| exopeptidase activity |
| tripeptidyl-peptidase activity |
| actin binding |
| carboxypeptidase activity |
| metalloendopeptidase activity |
| metallopeptidase activity |
| calmodulin binding |
| peptidyl-dipeptidase activity |
| zinc ion binding |
- Site Annotations
| Position | Description |
|---|---|
| 523 | Not glycosylated |
| 1225 | Not glycosylated |
Sequence
MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQWLLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRHS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 38 | N-linked (GlcNAc...) asparagine |
|
||
| 54 | N-linked (GlcNAc...) asparagine |
|
||
| 74 | N-linked (GlcNAc...) asparagine |
|
||
| 103 | N-linked (GlcNAc...) asparagine |
|
||
| 111 | N-linked (GlcNAc...) asparagine |
|
||
| 121 | N-linked (GlcNAc...) asparagine |
|
||
| 140 | N-linked (GlcNAc...) asparagine |
|
||
| 146 | N-linked (GlcNAc...) asparagine | |||
| 160 | N-linked (GlcNAc...) asparagine |
|
||
| 318 | N-linked (GlcNAc...) asparagine |
|
G53075ES
G05962QB
G30740WO
G70232NH
G55132BD
G69521XL
G35541EV
G13131HA
G49755GI
G16125XL
G68490OW
G86880BF
G28622IK
G80479JV
G85282JO
G87123QX
G79666IR
G92135MA
G98611JV
G02528FI
G45395BF
G07246CJ
G10819WX
G40926MX
G14972EH
G43223CG
G49906RN
G70441OD
G87661QW
G83646BJ
G60033FS
G41071NU
G07755XJ
G70619PT
G65184UU
G42124LM
G62765YT
G88619MM
G10019LZ
G11629QQ
G82830MN
G48414YA
G27058EU
G90659AW
G72790NZ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Metabolism of Angiotensinogen to Angiotensins | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070122 | Meckel syndrome 8 | |
| DOID:0070123 | congenital nongoitrous hypothyroidism 4 | |
| DOID:0070161 | hereditary sensory and autonomic neuropathy type 2 | |
| DOID:0070227 | intrahepatic cholestasis of pregnancy | |
| DOID:0070247 | autosomal dominant Emery-Dreifuss muscular dystrophy 2 | |
| DOID:0080001 | bone disease | |
| DOID:0080033 | craniometaphyseal dysplasia | |
| DOID:0080092 | myofibrillar myopathy 1 | |
| DOID:0080094 | myofibrillar myopathy 3 | |
| DOID:0080162 | lupus nephritis |
