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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Angiotensin-converting enzyme
Summary
- UniProt ID
- P12821
- Gene Symbol
-
- ACE
- DCP
- DCP1
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P12821
- PubChem
- P12821
- The Human Metabolome Database
- HMDBP01710
Annotation
- Keyword
-
- 3D-structure
- Alternative promoter usage
- Alternative splicing
- Calmodulin-binding
- Carboxypeptidase
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Phosphoprotein
- Reference proteome
- Repeat
- Secreted
- Signal
- Transmembrane helix
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| endopeptidase activity |
| exopeptidase activity |
| tripeptidyl-peptidase activity |
| actin binding |
| carboxypeptidase activity |
| metalloendopeptidase activity |
| metallopeptidase activity |
| calmodulin binding |
| peptidyl-dipeptidase activity |
| zinc ion binding |
- Site Annotations
| Position | Description |
|---|---|
| 523 | Not glycosylated |
| 1225 | Not glycosylated |
Sequence
MGAASGRRGPGLLLPLPLLLLLPPQPALALDPGLQPGNFSADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQNFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSNMSRIYSTAKVCLPNKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLQAGSSRPWQEVLKDMVGLDALDAQPLLKYFQPVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNSARSEGPLPDSGRVSFLGLDLDAQQARVGQWLLLFLGIALLVATLGLSQRLFSIRHRSLHRHSHGPQFGSEVELRHS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 368 | N-linked (GlcNAc...) asparagine |
|
||
| 445 | N-linked (GlcNAc...) asparagine | |||
| 509 | N-linked (GlcNAc...) asparagine | |||
| 523 |
|
|||
| 617 | N-linked (GlcNAc...) asparagine |
|
||
| 625 |
|
|
||
| 677 | N-linked (GlcNAc...) asparagine | |||
| 695 | N-linked (GlcNAc...) (complex) asparagine |
|
||
| 714 | N-linked (GlcNAc...) (complex) asparagine | |||
| 760 | N-linked (GlcNAc...) asparagine; partial |
|
G57888GL
G69521XL
G70888PK
G35541EV
G13131HA
G68490OW
G85282JO
G79666IR
G92135MA
G22310AV
G45395BF
G07246CJ
G14972EH
G43223CG
G48414YA
G87661QW
G83646BJ
G27058EU
G83460ZZ
G41071NU
G59536GA
G49642SA
G15664MX
G80223IX
G25418HZ
G24528MX
G85582CB
G70223PD
G72747WU
G08290VR
G46503DX
G25079LO
G70101JE
G80920RR
G42124LM
G90659AW
G62765YT
G64527OM
G28541PG
G31852PQ
G41247ZX
G02815KT
G92050GC
G28681TP
G58001LT
G54010QB
G74728JK
G37881RL
G65184UU
G65000LJ
G72790NZ
G49955PK
G93656SY
G11629QQ
G57776ZS
G60834IK
G52527GH
G56784JY
G87123QX
G85554PZ
G10819WX
G40926MX
G08918WF
G49906RN
G58087IP
G27915IV
G70441OD
G04657PL
G60033FS
G07755XJ
G86182NS
G70619PT
G06356OH
G59626AS
G05049YU
G84225JN
G35107SO
G10019LZ
G38663NM
G58954YZ
G46691LC
G29184RN
G92406TI
G01650EU
G02886BB
G59924QI
G10486CT
G72735IY
G18647XP
G95865ZB
G39446WN
G11314AS
G50282JC
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Metabolism of Angiotensinogen to Angiotensins | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0002116 | pterygium | |
| DOID:0014667 | disease of metabolism | |
| DOID:0040085 | bacterial sepsis | |
| DOID:0050083 | Keshan disease | |
| DOID:0050152 | aspiration pneumonia | |
| DOID:0050156 | idiopathic pulmonary fibrosis | |
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050430 | multiple endocrine neoplasia type 2A | |
| DOID:0050452 | mevalonic aciduria |
