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Major prion protein

Summary

UniProt ID

P13852

Gene Symbol

Prn
Prnp
Prp

Gene ID

24686

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P13852
Re-Glyco: P13852

Annotation

Keyword

Cell membrane
Copper
Direct protein sequencing
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Reference proteome
Repeat
Signal
Zinc

Gene Ontology (GO)

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GO Term
plasma membrane
membrane
inclusion body
dendrite
nuclear membrane
endoplasmic reticulum
Golgi apparatus
cytosol
cell surface
side of membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
learning or memory
negative regulation of type II interferon production
regulation of protein localization
negative regulation of apoptotic process
negative regulation of catalytic activity
positive regulation of neuron apoptotic process
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of long-term synaptic potentiation
positive regulation of glutamate receptor signaling pathway
negative regulation of dendritic spine maintenance

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GO Term
molecular function activator activity
cupric ion binding
amyloid-beta binding
protease binding
copper ion binding
glycosaminoglycan binding
microtubule binding
aspartic-type endopeptidase inhibitor activity
identical protein binding
transmembrane transporter binding

Annotation information from UniProt.

Sequence

MANLGYWLLALFVTTCTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQSGGTWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWSQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMLHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSAVLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites