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Protein lin-12
Summary
- UniProt ID
- P14585
- Gene Symbol
-
- R107.8
- lin-12
- Gene ID
- 176282
- Organism
- Caenorhabditis elegans
External Links
- Re-Glyco
- P14585
Annotation
- Keyword
-
- 3D-structure
- ANK repeat
- Activator
- Cell membrane
- Developmental protein
- Differentiation
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Notch signaling pathway
- Nucleus
- Reference proteome
- Repeat
- Signal
- Transcription regulation
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| plasma membrane |
| apical plasma membrane |
| CSL-Notch-Mastermind transcription factor complex |
| RNA polymerase II transcription regulator complex |
Sequence
MRIPTICFLFLLISLSKSLHIGSCLGLICGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQCDVSKCGADEKCVFDKDYRMETCVCKDCDINGNSLLKPSCPSGYGGDDCKTQGWCYPSVCMNGGQCIGAGNRAKCACPDGFKGERCELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADHPDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNPCSHGVCISFSGGFQCICDDGYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIPDICNHGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGFGGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQCKNGFIGKRCEKECPIGFGGVRCDLRLEIGICSRQGGKCFNGGKCLSGFCVCPPDFTGNQCEVNRKNGKSSLSENLCLSDPCMNNATCIDVDAHIGYACICKQGFEGDICERHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGGVCINEEEKGRKCECSYGFSGARCEEKINLTGFTEKDSLLRSVCEKRKCSERANDGNCDADCNYAACKFDGGDCSGKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDGMDCLPAVVRCPVKIREHCASRFANGICDPECNTNGCGFDGGDCDNETNATIITNIRITVQMDPKEFQVTGGQSLMEISSALRVTVRIQRDEEGPLVFQWNGESEMDRVKMNERQLTEQHVLSTSISRKIKRSATNIGVVVYLEVQENCDTGKCLYKDAQSVVDSISARLAKKGIDSFGIPISEALVAEPRKSGNNTGFLSWNALLLIGAGCLIVMVVLMLGALPGNRTRKRRMINASVWMPPMENEEKNRKNHQSITSSQHSLLEASYDGYIKRQRNELQHYSLYPNPQGYGNGNDFLGDFNHTNLQIPTEPEPESPIKLHTEAAGSYAITEPITRESVNIIDPRHNRTVLHWIASNSSAEKSEDLIVHEAKECIAAGADVNAMDCDENTPLMLAVLARRRRLVAYLMKAGADPTIYNKSERSALHQAAANRDFGMMVYMLNSTKLKGDIEELDRNGMTALMIVAHNEGRDQVASAKLLVEKGAKVDYDGAARKDSEKYKGRTALHYAAQVSNMPIVKYLVGEKGSNKDKQDEDGKTPIMLAAQEGRIEVVMYLIQQGASVEAVDATDHTARQLAQANNHHNIVDIFDRCRPEREYSMDLHIQHTHQPQPSRKVTRAPKKQTSRSKKESASNSRDSTHLTPPPSDGSTSTPSPQHFMNTTHTTPTSLNYLSPEYQTEAGSSEAFQPQCGAFGNGEMWYTRASTSYTQMQNEPMTRYSEPAHYF
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 41 | N-linked (GlcNAc...) asparagine |
|
||
| 165 | N-linked (GlcNAc...) asparagine |
|
||
| 194 | N-linked (GlcNAc...) asparagine |
|
||
| 378 | N-linked (GlcNAc...) asparagine |
|
||
| 515 | N-linked (GlcNAc...) asparagine |
|
||
| 623 | N-linked (GlcNAc...) asparagine |
|
||
| 751 | N-linked (GlcNAc...) asparagine |
|
||
| 754 | N-linked (GlcNAc...) asparagine |
|
||
| 900 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| NOTCH4 Activation and Transmission of Signal to the Nucleus | Caenorhabditis elegans |
| Negative regulation of NOTCH4 signaling | Caenorhabditis elegans |
| Pre-NOTCH Processing in Golgi | Caenorhabditis elegans |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10652 | Alzheimer's disease |
