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Insulin-like growth factor-binding protein 3

Summary

UniProt ID

P15473

Gene Symbol

Igfbp3
Igfbp-3

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P15473

Annotation

Keyword

Apoptosis
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 30 in total

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GO Term
regulation of cell growth
osteoblast differentiation
negative regulation of protein phosphorylation
apoptotic process
positive regulation of cardiac muscle cell apoptotic process
response to organic cyclic compound
negative regulation of smooth muscle cell migration
response to insulin
positive regulation of apoptotic process
type B pancreatic cell proliferation

Displaying **all 6** entries
GO Term
platelet alpha granule
heterochromatin
extracellular space
nucleus
insulin-like growth factor ternary complex
insulin-like growth factor binary complex

Displaying **all 5** entries
GO Term
protein tyrosine phosphatase activator activity
insulin-like growth factor I binding
insulin-like growth factor II binding
fibronectin binding
insulin-like growth factor binding

Annotation information from UniProt.

Sequence

MHPARPALWAAALTALTLLRGPPVARAGAGAVGAGPVVRCEPCDARALAQCAPPPTAPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLKALLNGRGFCANASAASNLSAYLPSQPSPGNTTESEEDHNAGSVESQVVPSTHRVTDSKFHPLHSKMEVIIKGQARDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYDTKGKDDVHCLSVQSQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
118	N-linked (GlcNAc...) asparagine	UniProt
124	N-linked (GlcNAc...) asparagine	UniProt
137	N-linked (GlcNAc...) asparagine	UniProt
200	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Post-translational protein phosphorylation	Rattus norvegicus
Regulation of IGF Activity by IGFBP	Rattus norvegicus
TP53 Regulates Transcription of Death Receptors and Ligands	Rattus norvegicus