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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
N-acetylglucosamine-6-sulfatase
Summary
- UniProt ID
- P15586
- Gene Symbol
-
- GNS
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011554
- GlyConnect
- GlyGen
- P15586
- PubChem
- P15586
- The Human Metabolome Database
- HMDBP01597
- The O-GlcNAc Database
- P15586
- O-GlcNAcAtlas
- P15586
Annotation
- Keyword
-
- Alternative splicing
- Calcium
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Hydrolase
- Lysosome
- Metal-binding
- Mucopolysaccharidosis
- Phosphoprotein
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| glycosaminoglycan catabolic process |
| keratan sulfate catabolic process |
| GO Term |
|---|
| azurophil granule lumen |
| lysosomal lumen |
| ficolin-1-rich granule lumen |
| extracellular region |
| extracellular exosome |
| GO Term |
|---|
| glycosaminoglycan binding |
| metal ion binding |
| sulfate binding |
| sulfuric ester hydrolase activity |
| N-acetylglucosamine-6-sulfatase activity |
Sequence
MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 48 |
|
|
||
| 106 |
|
|
||
| 111 | N-linked (GlcNAc...) asparagine | |||
| 112 |
|
|
||
| 117 | N-linked (GlcNAc...) asparagine | |||
| 178 |
|
|
||
| 183 | N-linked (GlcNAc...) asparagine |
|
||
| 198 | N-linked (GlcNAc...) asparagine | |||
| 210 | N-linked (GlcNAc...) asparagine | |||
| 275 |
|
G26377UA
G01521EA
G53075ES
G12745LE
G20577LS
G11101UV
G76915KR
G07810QS
G99679NM
G63136LV
G05962QB
G49755GI
G63980BQ
G04854VP
G94470IW
G20706XG
G00912UN
G15664MX
G85582CB
G46503DX
G80920RR
G90659AW
G77547TA
G62765YT
G28541PG
G31852PQ
G90575OW
G41247ZX
G50282JC
G53641QT
G20991XV
G45395BF
G07246CJ
G43223CG
G87661QW
G27058EU
G83460ZZ
G41071NU
G86182NS
G59626AS
G65184UU
G42124LM
G11870QZ
G47644PP
G72790NZ
G95177YH
G05049YU
G85269DF
G95865ZB
G49955PK
G23719VF
G11314AS
G39188ZX
G35029YA
G57776ZU
G36379GD
G02815KT
G84349RE
G57317CE
G92050GC
G74724QE
G92275SC
G14669DU
G28681TP
G81124ET
G70888PK
G80479JV
G43669FQ
G56307ZW
G87389XI
G36442WJ
G49018RC
G72747WU
G02886BB
G10486CT
G45504EY
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Keratan sulfate degradation | Homo sapiens |
| Lysosome Vesicle Biogenesis | Homo sapiens |
| MPS IIID - Sanfilippo syndrome D | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110307 | hypertrophic cardiomyopathy 1 | |
| DOID:0111390 | mucopolysaccharidosis Ih | |
| DOID:0111393 | mucopolysaccharidosis type IIIC | |
| DOID:0111394 | mucopolysaccharidosis type IIIB | |
| DOID:0111395 | mucopolysaccharidosis type IIIA | |
| DOID:0111402 | mucopolysaccharidosis type IIID | |
| DOID:10003 | sensorineural hearing loss | |
| DOID:1059 | intellectual disability | |
| DOID:11832 | visual epilepsy | |
| DOID:12798 | mucopolysaccharidosis |
