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Hepatocyte growth factor receptor

Summary

UniProt ID

P16056

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003421
PubChem: P16056

Annotation

Keyword

ATP-binding
Disulfide bond
Glycoprotein
Phosphoprotein
Proto-oncogene
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **31 - 40** of 49 in total

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GO Term
positive regulation of dendrite morphogenesis
modulation of chemical synaptic transmission
myoblast proliferation
cardiac muscle cell development
cardiac muscle contraction
regulation of cellular response to oxidative stress
positive regulation of endothelial cell chemotaxis
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
semaphorin-plexin signaling pathway
positive regulation of DNA replication

Displaying **all 10** entries
GO Term
extracellular space
membrane
postsynaptic membrane
dendrite
neuronal cell body
receptor complex
excitatory synapse
semaphorin receptor complex
sperm flagellum
basal plasma membrane

Displaying **all 9** entries
GO Term
protein kinase activity
protein tyrosine kinase activity
protein-containing complex binding
semaphorin receptor activity
phospholipase binding
hepatocyte growth factor receptor activity
ATP binding
beta-catenin binding
phosphatidylinositol 3-kinase binding

Annotation information from UniProt.

Sequence

MKAPTVLAPGILVLLLSLVQRSHGECKEALVKSEMNVNMKYQLPNFTAETPIQNVVLHGHHIYLGATNYIYVLNDKDLQKVSEFKTGPVLEHPDCLPCRDCSSKANSSGGVWKDNINMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNSADIQSEVHCMFSPEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPGYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFLDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPSDDILFGVFAQSKPDSAEPVNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARSDEYRTEFTTALQRVDLFMGRLNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHLTPHVNFLLDSHPVSPEVIVEHPSNQNGYTLVVTGKKITKIPLNGLGCGHFQSCSQCLSAPYFIQCGWCHNQCVRFDECPSGTWTQEICLPAVYKVFPTSAPLEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIISNSRETTQYSAFSYVDPVITSISPRYGPQAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVSDSILECYTPAQTTSDEFPVKLKIDLANRETSSFSYREDPVVYEIHPTKSFISGGSTITGIGKTLNSVSLPKLVIDVHEVGVNYTVACQHRSNSEIICCTTPSLKQLGLQLPLKTKAFFLLDGILSKHFDLTYVHNPVFEPFEKPVMISMGNENVVEIKGNNIDPEAVKGEVLKVGNQSCESLHWHSGAVLCTVPSDLLKLNSELNIEWKQAVSSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLLSGLFLWMRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHPKAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYVNVKCVAPYPSLLPSQDNIDGEGNT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **11 - 13** of 13 in total

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Position	Description	Source
760	O-linked (Man) threonine	UniProt
784	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt
878	N-linked (GlcNAc...) asparagine	GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Drug-mediated inhibition of MET activation	Mus musculus
MET Receptor Activation	Mus musculus
MET activates PI3K/AKT signaling	Mus musculus
MET activates PTK2 signaling	Mus musculus
MET activates PTPN11	Mus musculus
MET activates RAP1 and RAC1	Mus musculus
MET activates RAS signaling	Mus musculus
MET activates STAT3	Mus musculus
MET interacts with TNS proteins	Mus musculus
MET receptor recycling	Mus musculus

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UniCarb-DR

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International Collaboration

Acknowledgements