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MIRAGE
Sphingomyelin phosphodiesterase

Summary
UniProt ID
P17405
Gene Symbol
  • ASM
  • SMPD1
Gene ID
6609
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P17405
PubChem
P17405
SwissLipids
The Human Metabolome Database
HMDBP00776
Re-Glyco
P17405
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Glycosidase
  • Host-virus interaction
  • Lipid droplet
  • Lipid metabolism
  • Lysosome
  • Metal-binding
  • Neurodegeneration
  • Niemann-Pick disease
  • Phosphoprotein
  • Reference proteome
  • Secreted
  • Signal
  • Zinc
Gene Ontology (GO)
Displaying all 9 entries
GO Term
extracellular space
lysosome
plasma membrane
endosome
lipid droplet
endolysosome
lysosomal lumen
extracellular exosome
lamellar body
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MPRYGASLRQSCPRSGREQGQDGTAGAPGLLWMGLVLALALALALALALSDSRVLWAPAEAHPLSPQGHPARLHRIVPRLRDVFGWGNLTCPICKGLFTAINLGLKKEPNVARVGSVAIKLCNLLKIAPPAVCQSIVHLFEDDMVEVWRRSVLSPSEACGLLLGSTCGHWDIFSSWNISLPTVPKPPPKPPSPPAPGAPVSRILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLESLLSGLGPAGPFDMVYWTGDIPAHDVWHQTRQDQLRALTTVTALVRKFLGPVPVYPAVGNHESTPVNSFPPPFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYALSPYPGLRLISLNMNFCSRENFWLLINSTDPAGQLQWLVGELQAAEDRGDKVHIIGHIPPGHCLKSWSWNYYRIVARYENTLAAQFFGHTHVDEFEVFYDEETLSRPLAVAFLAPSATTYIGLNPGYRVYQIDGNYSGSSHVVLDHETYILNLTQANIPGAIPHWQLLYRARETYGLPNTLPTAWHNLVYRMRGDMQLFQTFWFLYHKGHPPSEPCGTPCRLATLCAQLSARADSPALCRHLMPDGSLPEAQSLWPRPLFC
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 8 entries
Position Description PubMed ID GlyTouCan ID Source
88 N-linked (GlcNAc...) asparagine
177 N-linked (GlcNAc...) asparagine
337 N-linked (GlcNAc...) asparagine
383
397 N-linked (GlcNAc...) asparagine
440
505 N-linked (GlcNAc...) asparagine
522 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying 1 entry
Pathway Name Organism
Glycosphingolipid catabolism Homo sapiens
Disease
Displaying all 3 entries
DO ID Disease Name Source
DOID:0070111 Niemann-Pick disease type A
DOID:0070112 Niemann-Pick disease type B
DOID:14504 Niemann-Pick disease
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025