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Prothrombin

Summary

UniProt ID

P19221

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003459
GlyGen: P19221
PubChem: P19221

Annotation

Keyword

3D-structure
Acute phase
Blood coagulation
Calcium
Cleavage on pair of basic residues
Disulfide bond
Gamma-carboxyglutamic acid
Glycoprotein
Kringle
Reference proteome
Repeat
Serine protease
Signal
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 28 in total

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GO Term
negative regulation of cytokine production involved in inflammatory response
ligand-gated ion channel signaling pathway
positive regulation of reactive oxygen species metabolic process
positive regulation of protein localization to nucleus
cytolysis by host of symbiont cells
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of release of sequestered calcium ion into cytosol
acute-phase response
positive regulation of protein phosphorylation
proteolysis

Displaying **all 3** entries
GO Term
extracellular space
collagen-containing extracellular matrix
external side of plasma membrane

Displaying **all 8** entries
GO Term
endopeptidase activity
serine-type endopeptidase activity
lipopolysaccharide binding
thrombospondin receptor activity
signaling receptor binding
calcium ion binding
heparin binding
peptidase activity

Annotation information from UniProt.

Sequence

MSHVRGLGLPGCLALAALVSLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGVNYLGTVNVTHTGIQCQLWRSRYPHKPEINSTTHPGADLKENFCRNPDSSTTGPWCYTTDPTVRREECSVPVCGQEGRTTVVMTPRSGGSKDNLSPPLGQCLTERGRLYQGNLAVTTLGSPCLPWNSLPAKTLSKYQDFDPEVKLVENFCRNPDWDEEGAWCYVAGQPGDFEYCNLNYCEEAVGEENYDVDESIAGRTTDAEFHTFFNEKTFGLGEADCGLRPLFEKKSLKDTTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYVHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLRAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQKVIDQFG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
122	N-linked (GlcNAc...) asparagine	17330941		GlycoProtDB UniProt GlyGen
144			G24748EV	GlycoProtDB UniProt GlyGen
413	N-linked (GlcNAc...) asparagine	17330941	G31986NC	UniProt GlyGen
553	N-linked (GlcNAc...) asparagine	17330941	G79652WX	GlycoProtDB UniProt GlyGen
			G49108TO	GlyGen