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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Hexokinase-1
Summary
- UniProt ID
- P19367
- Gene Symbol
-
- HK1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Allosteric enzyme
- Alternative splicing
- Charcot-Marie-Tooth disease
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Glycolysis
- Inflammatory response
- Innate immunity
- Intellectual disability
- Kinase
- Mitochondrion outer membrane
- Neurodegeneration
- Phosphoprotein
- Reference proteome
- Repeat
- Retinitis pigmentosa
- Gene Ontology (GO)
| GO Term |
|---|
| cytosol |
| mitochondrion |
| membrane raft |
| mitochondrial outer membrane |
| GO Term |
|---|
| glucokinase activity |
| hexokinase activity |
| ATP binding |
| fructokinase activity |
| glucose binding |
| mannokinase activity |
| peptidoglycan binding |
| glucosamine kinase activity |
Sequence
MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 821 |
|
|||
| 855 |
|
G49108TO
G47950XN
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective HK1 causes hexokinase deficiency (HK deficiency) | Homo sapiens |
| Glycolysis | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10241 | thalassemia | |
| DOID:0050524 | maturity-onset diabetes of the young | |
| DOID:0050534 | congenital stationary night blindness | |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | |
| DOID:0050572 | cone-rod dystrophy | |
| DOID:0050588 | muscular dystrophy-dystroglycanopathy type B1 | |
| DOID:0050635 | alternating hemiplegia of childhood | |
| DOID:0050819 | obsolete Matthew-Wood syndrome | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0060326 | myelomeningocele |
