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Synaptotagmin-1

Summary

UniProt ID

P21707

Gene Symbol

Syt1

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P21707
PubChem: P21707

Annotation

Keyword

3D-structure
Calcium
Cytoplasm
Cytoplasmic vesicle
Differentiation
Direct protein sequencing
Glycoprotein
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Repeat
Synapse
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 26 in total

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GO Term
regulation of calcium ion-dependent exocytosis
positive regulation of calcium ion-dependent exocytosis
synaptic vesicle endocytosis
calcium ion-regulated exocytosis of neurotransmitter
response to calcium ion
cellular response to calcium ion
regulation of regulated secretory pathway
positive regulation of dendrite extension
neurotransmitter secretion
regulation of dopamine secretion

Displaying entries **1 - 10** of 22 in total

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GO Term
synaptic vesicle
postsynaptic density
synaptic vesicle membrane
chromaffin granule membrane
presynaptic membrane
presynaptic active zone
excitatory synapse
hippocampal mossy fiber to CA3 synapse
glutamatergic synapse
terminal bouton

Displaying entries **1 - 10** of 16 in total

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GO Term
phosphatidylserine binding
calmodulin binding
phospholipid binding
calcium-dependent phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
syntaxin binding
clathrin binding
identical protein binding
protein heterodimerization activity
low-density lipoprotein particle receptor binding

Annotation information from UniProt.

Sequence

MVSASHPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQKFMNELHKIPLPPWALIAIAIVAVLLVVTCCFCVCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
24				UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Acetylcholine Neurotransmitter Release Cycle	Rattus norvegicus
Cargo recognition for clathrin-mediated endocytosis	Rattus norvegicus
Clathrin-mediated endocytosis	Rattus norvegicus
Dopamine Neurotransmitter Release Cycle	Rattus norvegicus
GABA synthesis, release, reuptake and degradation	Rattus norvegicus
Glutamate Neurotransmitter Release Cycle	Rattus norvegicus
Norepinephrine Neurotransmitter Release Cycle	Rattus norvegicus
Serotonin Neurotransmitter Release Cycle	Rattus norvegicus