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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Catechol O-methyltransferase
Summary
- UniProt ID
- P21964
- Gene Symbol
-
- COMT
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P21964
- PubChem
- P21964
- SwissLipids
- The Human Metabolome Database
- HMDBP00272
- RaftProt
- P21964
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Catecholamine metabolism
- Cell membrane
- Cytoplasm
- Direct protein sequencing
- Lipid metabolism
- Magnesium
- Metal-binding
- Methyltransferase
- Neurotransmitter degradation
- Phosphoprotein
- Reference proteome
- S-adenosyl-L-methionine
- Schizophrenia
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| gene expression |
| response to hypoxia |
| memory |
| response to wounding |
| response to toxic substance |
| dopamine secretion |
| developmental process |
| response to cytokine |
| norepinephrine secretion |
| renal filtration |
| GO Term |
|---|
| membrane |
| axon |
| dendrite |
| intracellular membrane-bounded organelle |
| synapse |
| extracellular exosome |
| cytosol |
| plasma membrane |
| GO Term |
|---|
| O-methyltransferase activity |
| magnesium ion binding |
| methyltransferase activity |
| catechol O-methyltransferase activity |
Sequence
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 91 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Enzymatic degradation of Dopamine by monoamine oxidase | Homo sapiens |
| Enzymatic degradation of dopamine by COMT | Homo sapiens |
| Methylation | Homo sapiens |
| Potential therapeutics for SARS | Homo sapiens |
Human Protein Atlas