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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alpha-(1,3)-fucosyltransferase 4
Summary
- UniProt ID
- P22083
- Gene Symbol
-
- FUT4
- ELFT
- FCT3A
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative initiation
- Glycoprotein
- Glycosyltransferase
- Golgi apparatus
- Inflammatory response
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| fucosylation |
| L-fucose catabolic process |
| lymphocyte migration into lymph node |
| Lewis x epitope biosynthetic process |
| positive regulation of leukocyte tethering or rolling |
| GO Term |
|---|
| Golgi membrane |
| Golgi apparatus |
| membrane |
| cell periphery |
| trans-Golgi network |
| cell surface |
| Golgi cisterna membrane |
| GO Term |
|---|
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity |
| alpha-(1->3)-fucosyltransferase activity |
| fucosyltransferase activity |
Sequence
MRRLWGAARKPSGAGWEKEWAEAPQEAPGAWSGRLGPGRSGRKGRAVPGWASWPAHLALAARPARHLGGAGQGPRPLHSGTAPFHSRASGERQRRLEPQLQHESRCRSSTPADAWRAEAALPVRAMGAPWGSPTAAAGGRRGWRRGRGLPWTVCVLAAAGLTCTALITYACWGQLPPLPWASPTPSRPVGVLLWWEPFGGRDSAPRPPPDCRLRFNISGCRLLTDRASYGEAQAVLFHHRDLVKGPPDWPPPWGIQAHTAEEVDLRVLDYEEAAAAAEALATSSPRPPGQRWVWMNFESPSHSPGLRSLASNLFNWTLSYRADSDVFVPYGYLYPRSHPGDPPSGLAPPLSRKQGLVAWVVSHWDERQARVRYYHQLSQHVTVDVFGRGGPGQPVPEIGLLHTVARYKFYLAFENSQHLDYITEKLWRNALLAGAVPVVLGPDRANYERFVPRGAFIHVDDFPSASSLASYLLFLDRNPAVYRRYFHWRRSYAVHITSFWDEPWCRVCQAVQRAGDRPKSIRNLASWFER
Glycosylation Sites
G57321FI
G40926MX
G41247ZX
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Lewis blood group biosynthesis | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:820 | myocarditis | |
| DOID:0040085 | bacterial sepsis | |
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050424 | familial adenomatous polyposis | |
| DOID:0050430 | multiple endocrine neoplasia type 2A | |
| DOID:0050458 | juvenile myelomonocytic leukemia | |
| DOID:0050523 | adult T-cell leukemia/lymphoma | |
| DOID:0050547 | familial medullary thyroid carcinoma | |
| DOID:0050571 | congenital disorder of glycosylation type II | |
| DOID:0050589 | inflammatory bowel disease |
