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MIRAGE
UDP-glucuronosyltransferase 1A1

Summary
UniProt ID
P22309
Gene Symbol
  • GNT1
  • UGT1
  • UGT1A1
Gene ID
54658
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P22309
PubChem
P22309
SwissLipids
The Human Metabolome Database
HMDBP00483
O-GlcNAcAtlas
P22309
Re-Glyco
P22309
Annotation
Keyword
  • Alternative splicing
  • Cytoplasm
  • Disease variant
  • Endoplasmic reticulum
  • Glycoprotein
  • Glycosyltransferase
  • Lipid metabolism
  • Reference proteome
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 6 entries
GO Term
plasma membrane
endoplasmic reticulum
endoplasmic reticulum membrane
perinuclear region of cytoplasm
cytochrome complex
endoplasmic reticulum chaperone complex
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 4 entries
Position Description PubMed ID GlyTouCan ID Source
102 N-linked (GlcNAc...) asparagine
295 N-linked (GlcNAc...) asparagine
338
347 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 5 entries
Pathway Name Organism
APAP ADME Homo sapiens
Aspirin ADME Homo sapiens
Defective UGT1A1 causes hyperbilirubinemia Homo sapiens
Glucuronidation Homo sapiens
Heme degradation Homo sapiens
Disease
Displaying entries 1 - 10 of 12 in total
DO ID Disease Name Source
DOID:10211 cholelithiasis
DOID:11151 cholecystolithiasis
DOID:1380 endometrial cancer
DOID:1612 breast cancer
DOID:2043 hepatitis B
DOID:2394 ovarian cancer
DOID:2739 Gilbert syndrome
DOID:2741 bilirubin metabolic disorder
DOID:3803 Crigler-Najjar syndrome
DOID:3908 lung non-small cell carcinoma
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025