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Prostaglandin G/H synthase 1
Summary
- UniProt ID
- P22437
- Gene Symbol
-
- Cox-1
- Cox1
- Ptgs1
- Gene ID
- 19224
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0003487
- PubChem
- P22437
- Re-Glyco
- P22437
Annotation
- Keyword
-
- Dioxygenase
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Heme
- Membrane
- Microsome
- Peroxidase
- Prostaglandin biosynthesis
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| endoplasmic reticulum membrane |
| Golgi apparatus |
| photoreceptor outer segment |
| cytoplasm |
| GO Term |
|---|
| prostaglandin-endoperoxide synthase activity |
| dioxygenase activity |
| metal ion binding |
| peroxidase activity |
| heme binding |
Sequence
MSRRSLSLWFPLLLLLLLPPTPSVLLADPGVPSPVNPCCYYPCQNQGVCVRFGLDNYQCDCTRTGYSGPNCTIPEIWTWLRNSLRPSPSFTHFLLTHGYWLWEFVNATFIREVLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDVQLLAQQLLLRREFIPAPQGTNILFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPERQMAVGQEVFGLLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIVIEEYVQHLSGYFLQLKFDPELLFRAQFQYRNRIAMEFNHLYHWHPLMPNSFQVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQRAGRIGGGRNFDYHVLHVAVDVIKESREMRLQPFNEYRKRFGLKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCQPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKPSTFGGDVGFNLVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVLVRRSTEL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 70 | N-linked (GlcNAc...) asparagine |
|
||
| 106 | N-linked (GlcNAc...) asparagine |
|
||
| 146 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| COX reactions | Mus musculus |
| Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10591 | pre-eclampsia |
