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Insulin-like growth factor 1 receptor

Summary

UniProt ID

P24062

Gene Symbol

Igf1r

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P24062

Annotation

Keyword

ATP-binding
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Isopeptide bond
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
positive regulation of developmental growth
positive regulation of DNA metabolic process
positive regulation of meiotic cell cycle
positive regulation of steroid hormone biosynthetic process
mitotic nuclear division
postsynaptic modulation of chemical synaptic transmission
adrenal gland development
exocrine pancreas development
positive regulation of cold-induced thermogenesis
MAPK cascade

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GO Term
caveola
protein kinase complex
insulin receptor complex

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GO Term
identical protein binding
insulin receptor substrate binding
protein-containing complex binding
G-protein alpha-subunit binding
protein tyrosine kinase activity
insulin-like growth factor receptor activity
insulin-like growth factor I binding
phosphatidylinositol 3-kinase binding
insulin binding
insulin-like growth factor binding

Annotation information from UniProt.

Sequence

MKSGSGGGSPTSLWGLVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVENNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEMEPSFQEVSFYYSEENKPPEPEELEMELELEPENMESVPLDPSASSASLPLPERHSGHKAENGPGVLVLRASFDERQPYAHMNGGRANERALPLPQSSTC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
641	N-linked (GlcNAc...) asparagine	UniProt
748	N-linked (GlcNAc...) asparagine	UniProt
757	N-linked (GlcNAc...) asparagine	UniProt
765	N-linked (GlcNAc...) asparagine	UniProt
901	N-linked (GlcNAc...) asparagine	UniProt
914	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Extra-nuclear estrogen signaling	Rattus norvegicus
IRS-related events triggered by IGF1R	Rattus norvegicus
SHC-related events triggered by IGF1R	Rattus norvegicus
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements