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Insulin-like growth factor 1 receptor

Summary

UniProt ID

P24062

Gene Symbol

Igf1r

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P24062

Annotation

Keyword

ATP-binding
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Isopeptide bond
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
insulin receptor signaling pathway
response to hormone
cerebellum development
hippocampus development
neuron projection development
response to insulin
cellular response to insulin stimulus
negative regulation of hepatocyte apoptotic process
cellular response to aldosterone
negative regulation of cholangiocyte apoptotic process

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GO Term
caveola
protein kinase complex
insulin receptor complex

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GO Term
insulin-like growth factor binding
protein transporter activity
identical protein binding
insulin receptor substrate binding
protein-containing complex binding
G-protein alpha-subunit binding
protein tyrosine kinase activity
insulin-like growth factor receptor activity
insulin-like growth factor I binding
phosphatidylinositol 3-kinase binding

Annotation information from UniProt.

Sequence

MKSGSGGGSPTSLWGLVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTIDWSLILDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSVCGKRACTENNECCHPECLGSCHTPDDNTTCVACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSDSDGFVIHDGECMQECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKEGEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYIVRWQRQPQDGYLFRHNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVLQVANTTMSSRSRNTTVADTYNITDPEEFETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALPVAILLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVENNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKDEMEPSFQEVSFYYSEENKPPEPEELEMELELEPENMESVPLDPSASSASLPLPERHSGHKAENGPGVLVLRASFDERQPYAHMNGGRANERALPLPQSSTC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
51	N-linked (GlcNAc...) asparagine	UniProt
102	N-linked (GlcNAc...) asparagine	UniProt
135	N-linked (GlcNAc...) asparagine	UniProt
245	N-linked (GlcNAc...) asparagine	UniProt
314	N-linked (GlcNAc...) asparagine	UniProt
418	N-linked (GlcNAc...) asparagine	UniProt
439	N-linked (GlcNAc...) asparagine	UniProt
535	N-linked (GlcNAc...) asparagine	UniProt
608	N-linked (GlcNAc...) asparagine	UniProt
623	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Extra-nuclear estrogen signaling	Rattus norvegicus
IRS-related events triggered by IGF1R	Rattus norvegicus
SHC-related events triggered by IGF1R	Rattus norvegicus
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements