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Amphiregulin

Summary

UniProt ID

P24338

Gene Symbol

Areg
Sdgf

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P24338

Annotation

Keyword

Cytokine
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 19 in total

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GO Term
G protein-coupled receptor signaling pathway
positive regulation of cell population proliferation
positive regulation of phosphorylation
glial cell proliferation
response to organic cyclic compound
neuron projection development
response to estradiol
response to peptide hormone
negative regulation of osteoblast differentiation
positive regulation of peptidyl-tyrosine phosphorylation

Displaying **all 5** entries
GO Term
cell surface
extracellular space
nucleus
cytoplasm
membrane

Displaying **all 5** entries
GO Term
transmembrane receptor protein tyrosine kinase activator activity
cytokine activity
receptor ligand activity
epidermal growth factor receptor binding
growth factor activity

Annotation information from UniProt.

Sequence

MRTPSLSLALSVLSLLVLGSGHYAAGLELNGTSSGKGEPSSGDHSAGGLVVSEVSTISEMPSGSELSTGDYDYSEEYDNEPQISGYIVDDSVRVEQVIKPKENKTEGEKSSEKPKRKKKGGKGGKGRRNRKKKKNPCAAKFQNFCIHGECRYIENLEVVTCHCHQDYFGERCGEKTMKTQKKDDSDLSKIALAAIIVFVSAVSVAAIGIITAVLLRKRFFREYEEAEERRRLRQENGTAHAIA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
30	N-linked (GlcNAc...) asparagine	UniProt
103	N-linked (GlcNAc...) asparagine	UniProt
236	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **11 - 14** of 14 in total

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Pathway Name	Organism
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Rattus norvegicus
RAF/MAP kinase cascade	Rattus norvegicus
SHC1 events in EGFR signaling	Rattus norvegicus
Signaling by EGFR	Rattus norvegicus