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Tumor necrosis factor receptor superfamily member 1A

Summary

UniProt ID

P25118

Gene Symbol

Tnfr-1
Tnfr1
Tnfrsf1a

Gene ID

21937

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003512
PubChem: P25118
Re-Glyco: P25118

Annotation

Keyword

Apoptosis
Cell membrane
Disulfide bond
Glycoprotein
Golgi apparatus
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
cell surface
membrane raft
extracellular space
plasma membrane
receptor complex
Golgi membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 28 in total

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GO Term
positive regulation of transcription by RNA polymerase II
pulmonary valve development
receptor signaling pathway via JAK-STAT
regulation of tumor necrosis factor-mediated signaling pathway
regulation of establishment of endothelial barrier
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of execution phase of apoptosis
positive regulation of apoptotic process involved in morphogenesis
regulation of membrane lipid metabolic process
negative regulation of extracellular matrix constituent secretion

Displaying **all 3** entries
GO Term
tumor necrosis factor receptor activity
signaling receptor activity
tumor necrosis factor binding

Annotation information from UniProt.

Sequence

MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	Source
54	N-linked (GlcNAc...) asparagine		UniProt
151	N-linked (GlcNAc...) asparagine		GlycoProtDB UniProt
202	N-linked (GlcNAc...) asparagine		UniProt
376	(Microbial infection) N-beta-linked (GlcNAc) arginine	30902834	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Regulation of TNFR1 signaling	Mus musculus
TNF signaling	Mus musculus
TNFR1-induced NF-kappa-B signaling pathway	Mus musculus
TNFR1-induced proapoptotic signaling	Mus musculus
TNFR1-mediated ceramide production	Mus musculus
TNFs bind their physiological receptors	Mus musculus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090018	TNF receptor–associated periodic syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements