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MIRAGE
Tumor necrosis factor receptor superfamily member 6

Summary
UniProt ID
P25445
Gene Symbol
  • APT1
  • FAS
  • FAS1
  • TNFRSF6
Gene ID
355
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P25445
PubChem
P25445
RaftProt
P25445
Re-Glyco
P25445
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Apoptosis
  • Calmodulin-binding
  • Cell membrane
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Palmitate
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Secreted
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 9 entries
GO Term
death-inducing signaling complex
CD95 death-inducing signaling complex
membrane raft
extracellular exosome
nuclear body
plasma membrane
cytosol
external side of plasma membrane
cell surface
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 12 in total
Position Description PubMed ID GlyTouCan ID Source
28 O-linked (GalNAc...) threonine
38
39
40
42
43
46
118 N-linked (GlcNAc...) asparagine
132
136 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 7 entries
Pathway Name Organism
CASP8 activity is inhibited Homo sapiens
Dimerization of procaspase-8 Homo sapiens
FasL/ CD95L signaling Homo sapiens
Ligand-dependent caspase activation Homo sapiens
RIPK1-mediated regulated necrosis Homo sapiens
Regulation by c-FLIP Homo sapiens
TP53 Regulates Transcription of Death Receptors and Ligands Homo sapiens
Disease
Displaying entries 1 - 10 of 20 in total
DO ID Disease Name Source
DOID:0050523 adult T-cell leukemia/lymphoma
DOID:0060704 lymphoproliferative syndrome
DOID:0080797 nasal type extranodal NK/T-cell lymphoma
DOID:10283 prostate cancer
DOID:10591 pre-eclampsia
DOID:10652 Alzheimer's disease
DOID:11054 urinary bladder cancer
DOID:13133 HELLP syndrome
DOID:1485 cystic fibrosis
DOID:1612 breast cancer
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025