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MIRAGE
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Summary
- UniProt ID
- P30153
- Gene Symbol
-
- PPP2R1A
- Gene ID
- 5518
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Cell membrane
- Cell projection
- Centromere
- Chromosome
- Chromosome partition
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Host-virus interaction
- Intellectual disability
- Nucleus
- Reference proteome
- Repeat
- Gene Ontology (GO)
| GO Term |
|---|
| dendrite |
| neuron projection |
| neuronal cell body |
| cytosol |
| chromosome, centromeric region |
| GO Term |
|---|
| protein phosphatase regulator activity |
| protein antigen binding |
| protein serine/threonine phosphatase activity |
| protein heterodimerization activity |
Sequence
MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 553 |
|
|||
| 555 |
|
G62765YT
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| APC truncation mutants have impaired AXIN binding | Homo sapiens |
| AURKA Activation by TPX2 | Homo sapiens |
| AXIN missense mutants destabilize the destruction complex | Homo sapiens |
| Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | Homo sapiens |
| Anchoring of the basal body to the plasma membrane | Homo sapiens |
| Beta-catenin phosphorylation cascade | Homo sapiens |
| CTLA4 inhibitory signaling | Homo sapiens |
| CTNNB1 S33 mutants aren't phosphorylated | Homo sapiens |
| CTNNB1 S37 mutants aren't phosphorylated | Homo sapiens |
| CTNNB1 S45 mutants aren't phosphorylated | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070066 | autosomal dominant intellectual developmental disorder 36 |
