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Gamma-aminobutyric acid receptor subunit alpha-5

Summary

UniProt ID

P31644

Gene Symbol

GABRA5

Gene ID

2558

Organism

Homo sapiens (human)

External Links

GlyGen: P31644
PubChem: P31644
The Human Metabolome Database: HMDBP08202
Re-Glyco: P31644

Annotation

Keyword

3D-structure
Cell membrane
Chloride channel
Disease variant
Disulfide bond
Epilepsy
Glycoprotein
Isopeptide bond
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 14 in total

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GO Term
synapse
postsynapse
nucleoplasm
cytosol
dendrite membrane
neuronal cell body membrane
presynaptic membrane
transmembrane transporter complex
chloride channel complex
plasma membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 11 in total

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GO Term
regulation of postsynaptic membrane potential
signal transduction
chloride transmembrane transport
inhibitory synapse assembly
gamma-aminobutyric acid signaling pathway
associative learning
inner ear receptor cell development
innervation
cochlea development
synaptic transmission, GABAergic

Displaying **all 6** entries
GO Term
signaling receptor activity
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
GABA receptor binding
GABA-gated chloride ion channel activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
GABA-A receptor activity

Annotation information from UniProt.

Sequence

MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	Source
45	N-linked (GlcNAc...) asparagine		UniProt GlyGen
145	N-linked (GlcNAc...) asparagine	30140029	UniProt GlyGen
207	N-linked (GlcNAc...) asparagine		UniProt GlyGen
236	N-linked (GlcNAc...) asparagine	30140029	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
GABA receptor activation	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0112215	developmental and epileptic encephalopathy 79	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:3312	bipolar disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements