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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alpha-L-iduronidase
Summary
- UniProt ID
- P35475
- Gene Symbol
-
- IDUA
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- P35475
- PubChem
- P35475
- The Human Metabolome Database
- HMDBP01593
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Disease variant
- Disulfide bond
- Glycoprotein
- Glycosidase
- Lysosome
- Mucopolysaccharidosis
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular exosome |
| lysosomal lumen |
| GO Term |
|---|
| signaling receptor binding |
| L-iduronidase activity |
Sequence
MRPLRPRAALLALLASLLAAPPVAPAEAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 110 | N-linked (GlcNAc...) asparagine | |||
| 190 | N-linked (GlcNAc...) asparagine |
|
||
| 336 | N-linked (GlcNAc...) asparagine |
|
||
| 372 | N-linked (GlcNAc...) asparagine | |||
| 415 | N-linked (GlcNAc...) asparagine | |||
| 451 | N-linked (GlcNAc...) asparagine | |||
|
|
|
G02815KT
G06110VR
G74724QE
G92275SC
G83460ZZ
G70101JE
G64527OM
G66676MI
G92406TI
G62765YT
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CS/DS degradation | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
| MPS I - Hurler syndrome | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9275 | tyrosinemia | |
| DOID:0050726 | tyrosinemia type I | |
| DOID:0014667 | disease of metabolism | |
| DOID:0050387 | nonpapillary renal cell carcinoma | |
| DOID:0050466 | Loeys-Dietz syndrome | |
| DOID:0050589 | inflammatory bowel disease | |
| DOID:0050590 | severe congenital neutropenia | |
| DOID:0050700 | cardiomyopathy | |
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0050902 | medulloblastoma |
