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Cystathionine beta-synthase

Summary

UniProt ID

P35520

Gene Symbol

Organism

Homo sapiens (human)

External Links

GlyGen: P35520
PubChem: P35520
The Human Metabolome Database: HMDBP00779
The O-GlcNAc Database: P35520

Annotation

Keyword

3D-structure
Allosteric enzyme
Alternative splicing
CBS domain
Cysteine biosynthesis
Cytoplasm
Disease variant
Heme
Isopeptide bond
Lyase
Nucleus
Phosphoprotein
Pyridoxal phosphate
Reference proteome
Ubl conjugation

Gene Ontology (GO)

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GO Term
cysteine biosynthetic process via cystathionine
transsulfuration
L-cysteine catabolic process
response to folic acid
homocysteine catabolic process
L-serine metabolic process
homocysteine metabolic process
blood vessel diameter maintenance
cysteine biosynthetic process
cysteine biosynthetic process from serine

Displaying **all 3** entries
GO Term
cytoplasm
nucleus
cytosol

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GO Term
heme binding
pyridoxal phosphate binding
ubiquitin protein ligase binding
nitrite reductase (NO-forming) activity
identical protein binding
protein homodimerization activity
cystathionine beta-synthase activity
cysteine synthase activity
carbon monoxide binding
L-cysteine desulfhydrase activity

Annotation information from UniProt.

Sequence

MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites